s38093

Product Name: s38093
CAS No.: 1222097-72-4
Chemical Name: s38093
Synonyms: s38093;S38093 HCl;S 38093 HydrochL;S 38093 Hydrochloride;S 38093 HCl, 10 mM in DMSO;S 38093; S38093; S-38093; S38093 HCL;4-(3-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)benzamide hydrochloride
CBNumber: CB83350593
Molecular Formula: C17H25ClN2O2
Formula Weight: 324.85
MOL File: 1222097-72-4.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 6778
Product name: S38093
Purity: ≥98%(HPLC)
Packaging: 25
Price: $278
Updated: 2021/12/16

DC Chemicals

Product number: DC11271
Product name: S38093HCl
Purity: >98%
Packaging: 100mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC11271
Product name: S38093HCl
Purity: >98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC11271
Product name: S38093HCl
Purity: >98%
Packaging: 1g
Price: $1850
Updated: 2021/12/16

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s38093 Chemical Properties,Usage,Production

Description

S38093 is an inverse agonist at histamine H3 receptors. S 38093 displays a moderate affinity for rat, mouse and human H3 receptors (Ki=8.8, 1.44 and 1.2μM, respectively) with no affinity for other histaminergic receptors. In cellular models, the compound was able to antagonize mice H3 receptors (KB=0.65μM) and to suppress cAMP decrease induced by an H3 agonist via human H3 receptors (KB=0.11μM).

Uses

S 38093 hydrochloride is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 μM for rat, mouse and human H3 receptors, respectively.

in vivo

S 38093 (0.3 and 3mg/kg/d p.o., 28 days) significantly increases proliferation of progenitors in the DG of hippocampus in young adult mice. S 38093 (0.3mg/kg/d) treatment significantly increases the number of DCX⁺ cells with tertiary dendrites. S 38093 (0.3, 1 and/or 3mg/kg) significantly increases cell proliferation, survival, and maturation in the DG of hippocampus in aged mice relative to vehicle. S 38093 (3mg/kg/d p.o., 28 days) increases cell proliferation and has a strong effect on cell survival, also increases the dendritic intersections in both genotypes (one-way ANOVA with repeated measure, p<0.01), with a significant effect from 50 to 80 in APPSWE^TG mice only. In aged mice, chronic administration of S 38093 (1 and/or 3mg/kg/day p.o., 28 days) reverses this age-dependent decrease in BDNF-IX, BDNF-IV and BDNF-I transcripts. In addition, S 38093 at three tested doses (0.3, 1 and 3mg/kg/d) increases VEGF transcripts compared to vehicle-aged group^[1]. In mice, S 38093 significantly increases ex vivo N-tele-Methylhistamine cerebral levels from 3 mg/kg p.o. and antagonized R-α-Methylhistamine-induced dipsogenia from 10 mg/kg i.p^[2].

References

[1] Guilloux JP, et al. S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946. DOI:10.1038/srep42946
[2] Sors A, et al. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23 DOI:10.1016/j.ejphar.2017.03.013

s38093 Preparation Products And Raw materials

Raw materials

Preparation Products

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s38093 Suppliers

China 39 India 1 United States 4 Global 44

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71615
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9666
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7998
Advantage: 62

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9829
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32469
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

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View Lastest Price from s38093 manufacturers

Career Henan Chemical Co

Product: s38093 1222097-72-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

1222097-72-4, s38093Related Search:

S 38093; S38093; S-38093; S38093 HCL

s38093

S38093 HCl

S 38093 Hydrochloride

S 38093 HydrochL

4-(3-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)benzamide hydrochloride

S 38093 HCl, 10 mM in DMSO

1222097-72-4

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