s38093
- Product Name
- s38093
- CAS No.
- 1222097-72-4
- Chemical Name
- s38093
- Synonyms
- s38093;S38093 HCl;S 38093 HydrochL;S 38093 Hydrochloride;S 38093 HCl, 10 mM in DMSO;S 38093; S38093; S-38093; S38093 HCL;4-(3-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)benzamide hydrochloride
- CBNumber
- CB83350593
- Molecular Formula
- C17H25ClN2O2
- Formula Weight
- 324.85
- MOL File
- 1222097-72-4.mol
N-Bromosuccinimide Price
- Product number
- 6778
- Product name
- S38093
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $278
- Updated
- 2021/12/16
- Product number
- DC11271
- Product name
- S38093HCl
- Purity
- >98%
- Packaging
- 100mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- DC11271
- Product name
- S38093HCl
- Purity
- >98%
- Packaging
- 250mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- DC11271
- Product name
- S38093HCl
- Purity
- >98%
- Packaging
- 1g
- Price
- $1850
- Updated
- 2021/12/16
s38093 Chemical Properties,Usage,Production
Description
S38093 is an inverse agonist at histamine H3 receptors. S 38093 displays a moderate affinity for rat, mouse and human H3 receptors (Ki=8.8, 1.44 and 1.2μM, respectively) with no affinity for other histaminergic receptors. In cellular models, the compound was able to antagonize mice H3 receptors (KB=0.65μM) and to suppress cAMP decrease induced by an H3 agonist via human H3 receptors (KB=0.11μM).
Uses
S 38093 hydrochloride is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 μM for rat, mouse and human H3 receptors, respectively.
in vivo
S 38093 (0.3 and 3?mg/kg/d p.o., 28 days) significantly increases proliferation of progenitors in the DG of hippocampus in young adult mice. S 38093 (0.3?mg/kg/d) treatment significantly increases the number of DCX+ cells with tertiary dendrites. S 38093 (0.3, 1 and/or 3?mg/kg) significantly increases cell proliferation, survival, and maturation in the DG of hippocampus in aged mice relative to vehicle. S 38093 (3?mg/kg/d p.o., 28 days) increases cell proliferation and has a strong effect on cell survival, also increases the dendritic intersections in both genotypes (one-way ANOVA with repeated measure, p?<?0.01), with a significant effect from 50 to 80 in APPSWETG mice only. In aged mice, chronic administration of S 38093 (1 and/or 3?mg/kg/day p.o., 28 days) reverses this age-dependent decrease in BDNF-IX, BDNF-IV and BDNF-I transcripts. In addition, S 38093 at three tested doses (0.3, 1 and 3?mg/kg/d) increases VEGF transcripts compared to vehicle-aged group[1]. In mice, S 38093 significantly increases ex vivo N-tele-Methylhistamine cerebral levels from 3 mg/kg p.o. and antagonized R-α-Methylhistamine-induced dipsogenia from 10 mg/kg i.p[2].
References
[1] Guilloux JP, et al. S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946. DOI:10.1038/srep42946
[2] Sors A, et al. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23 DOI:10.1016/j.ejphar.2017.03.013
s38093 Preparation Products And Raw materials
Raw materials
Preparation Products
s38093 Suppliers
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View Lastest Price from s38093 manufacturers
- Product
- s38093 1222097-72-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23