Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl)
- Product Name
- Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl)
- CAS No.
- 312608-54-1
- Chemical Name
- Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl)
- Synonyms
- ChemBridge5655896;MID-1, 10 mM in DMSO;4-ethoxy-N-(5-nitrothiazol-2-yl)benzamide;Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl);4-ethoxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide;MID-1,inhibit,Inhibitor,MG53,ubiquitination,Insulin Receptor,insulin,association,glucose,MID1,IRS-1,MID 1,degradation
- CBNumber
- CB83352890
- Molecular Formula
- C12H11N3O4S
- Formula Weight
- 293.3
- MOL File
- 312608-54-1.mol
Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl) Property
- Density
- 1.442±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 31.25 mg/mL (106.55 mM)
- pka
- 6.62±0.50(Predicted)
- form
- Solid
- color
- Orange to red
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0087004
- Product name
- MID-1
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0087004
- Product name
- MID-1
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0087004
- Product name
- MID-1
- Packaging
- 25mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0087004
- Product name
- MID-1
- Packaging
- 50mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0087004
- Product name
- MID-1
- Packaging
- 100mg
- Price
- $1200
- Updated
- 2021/12/16
Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl) Chemical Properties,Usage,Production
Uses
MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake[1].
in vivo
MID-1 does not have good pharmacokinetics in vivo[1].
References
[1] Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635. DOI:10.1074/jbc.M116.754424
Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl) Preparation Products And Raw materials
Raw materials
Preparation Products
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