PF-06471553
- Product Name
- PF-06471553
- CAS No.
- 1808094-07-6
- Chemical Name
- PF-06471553
- Synonyms
- PF-06471553;PF 06471553,PF06471553;1H-Isoindole-5-sulfonamide, N-(2-cyclobutyl-2H-1,2,3-triazol-4-yl)-2,3-dihydro-2-[2-(3-methoxyphenyl)acetyl]-
- CBNumber
- CB83355457
- Molecular Formula
- C23H25N5O4S
- Formula Weight
- 467.54
- MOL File
- 1808094-07-6.mol
PF-06471553 Property
- Boiling point:
- 728.7±70.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (320.83 mM)
- form
- Solid
- pka
- 6.75±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0028403
- Product name
- PF-06471553
- Purity
- 98.29%
- Packaging
- 5mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0028403
- Product name
- PF-06471553
- Purity
- 98.29%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0028403
- Product name
- PF-06471553
- Purity
- 98.29%
- Packaging
- 25mg
- Price
- $1750
- Updated
- 2021/12/16
- Product number
- CS-0028403
- Product name
- PF-06471553
- Purity
- 98.29%
- Packaging
- 50mg
- Price
- $2750
- Updated
- 2021/12/16
- Product number
- CS-0028403
- Product name
- PF-06471553
- Purity
- 98.29%
- Packaging
- 100mg
- Price
- $3950
- Updated
- 2021/12/16
PF-06471553 Chemical Properties,Usage,Production
Description
PF-06471553 is a potent and selective Monoacylglycerol acyltransferase 3 (MGAT3) inhibitor. PF-06471553 selectively inhibits MGAT3 with high in vitro potency and cell efficacy. In the presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2) inhibitors, an oral administration of PF-06471553 exhibited inhibition of the incorporation of deuterium-labeled glycerol into TAG in mouse model. Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising strategy to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis.
Uses
PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.
in vivo
PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice[1].
References
[1] Huard K, et al. Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3. J Med Chem. 2015 Sep 24;58(18):7164-72. DOI:10.1021/acs.jmedchem.5b01008
PF-06471553 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-06471553 Suppliers
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6355
- Advantage
- 58
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29760
- Advantage
- 68
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 15121162054
- Country
- CHINA
- ProdList
- 635
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ：2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 13901585132
- 2261760024@qq.com
- Country
- China
- ProdList
- 4900
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9835
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 400-025-6535
- sales@adooq.cn
- Country
- China
- ProdList
- 6215
- Advantage
- 58
- Tel
- 17765667235
- Country
- CHINA
- ProdList
- 129
- Advantage
- 58
- Tel
- 18933223435
- Country
- CHINA
- ProdList
- 198
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58