MK204

Product Name: MK204
CAS No.: 1959605-73-2
Chemical Name: MK204
Synonyms: MK204;MK204 >=98% (HPLC);Acetic acid, 2-[5-chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-
CBNumber: CB83357936
Molecular Formula: C16H9Br5ClNO4
Formula Weight: 714.22
MOL File: 1959605-73-2.mol

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MK204 Property

Boiling point:: 721.4±60.0 °C(Predicted)
Density: 2.242±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 3mg/mL, clear (warmed)
form: powder
pka: 2.94±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1890
Product name: MK204
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $91.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1890
Product name: MK204
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $413
Updated: 2023/01/07

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MK204 Chemical Properties,Usage,Production

Uses

MK204 is an aldose reductase (AR) inhibitor that can be used in diabetes research[1].

Biological Activity

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC50 value of 80 nM compared to an IC50 value of 21.7 μM for aldose reductase.

References

[1] Cousido-Siah A, et al. IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. ACS Chem Biol. 2016 Oct 21;11(10):2693-2705. DOI:10.1021/acschembio.6b00382

MK204 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK204 Suppliers

China 8 United States 3 Global 11

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Beijing Biocreative Technology Co., Ltd.

Tel: 15522676233
Email: 3007606172@qq.com
Country: China
ProdList: 1248
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

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View Lastest Price from MK204 manufacturers

Career Henan Chemical Co

Product: MK204 1959605-73-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-24

1959605-73-2, MK204Related Search:

MK204

MK204 >=98% (HPLC)

Acetic acid, 2-[5-chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-

1959605-73-2