ChemicalBook > CAS DataBase List > 5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile

5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile

Product Name
5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile
CAS No.
1179347-65-9
Chemical Name
5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile
Synonyms
MT 63-78;MT 63-78, 10 mM in DMSO;5-[4-(2,6-dihydroxyphenyl)phenyl]-1H-indole-3-carbonitrile;5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile;1H-Indole-3-carbonitrile, 5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-;Raptor,mitotic,Mammalian target of Rapamycin,direct,antitumor,MT 63-78,mTOR,Thr172,arrest,dephosphorylation,Inhibitor,AMP-activated protein kinase,Mcl-1,mTORC1,Apoptosis,AMPK,MT 63 78,lipogenesis,BH3,MT 6378,p53,inhibit
CBNumber
CB83358519
Molecular Formula
C21H14N2O2
Formula Weight
326.35
MOL File
1179347-65-9.mol
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5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile Property

storage temp. 
4°C, protect from light
form 
Solid
color 
Light yellow to brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0050703
Product name
MT63-78
Packaging
100mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0050703
Product name
MT63-78
Packaging
250mg
Price
$900
Updated
2021/12/16
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5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile Chemical Properties,Usage,Production

Uses

MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects[1].

in vivo

MT 63-78 (30 mg/kg; intraperitoneal injection; daily; for 14 days; C57 BL/6 male mice) treatment leads to a 33% inhibition of tumor growth[1].

Animal Model:C57 BL/6 male mice bearing LNCaP tumors[1]
Dosage:30 mg/kg
Administration: Intraperitoneal injection; daily; for 14 days
Result:Led to a 33% inhibition of tumor growth.

IC 50

AMPK: 25 μM (EC50); mTORC1

References

[1] Zadra G, et al. A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med. 2014 Apr;6(4):519-38. DOI:10.1002/emmm.201302734

5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile Suppliers

China 39 United States 2 Global 41
Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
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sales@3stc.com
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China
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3764
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Wuhan Kaymke Chemical Co., Ltd.,
Tel
027-027-87342388 18086026008
Fax
027-87342388
Email
sales@kaymke.com
Country
China
ProdList
3731
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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8000
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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Aikon International Limited
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02557626880
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Shanghai Hongye Biotechnology Co. Ltd
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ROSEWA HOLDING GROUP CO.,LIMITED
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+86-023-62871537
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1179347-65-9, 5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrileRelated Search:


  • MT 63-78
  • 5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile
  • 1H-Indole-3-carbonitrile, 5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-
  • 5-[4-(2,6-dihydroxyphenyl)phenyl]-1H-indole-3-carbonitrile
  • Raptor,mitotic,Mammalian target of Rapamycin,direct,antitumor,MT 63-78,mTOR,Thr172,arrest,dephosphorylation,Inhibitor,AMP-activated protein kinase,Mcl-1,mTORC1,Apoptosis,AMPK,MT 63 78,lipogenesis,BH3,MT 6378,p53,inhibit
  • MT 63-78, 10 mM in DMSO
  • 1179347-65-9