VAL-CIT-PAB-MMAD

Product Name: VAL-CIT-PAB-MMAD
CAS No.: 1415329-13-3
Chemical Name: VAL-CIT-PAB-MMAD
Synonyms: Vat-Cit-PAB-MMAD;VAL-CIT-PAB-MMAD;Vat-Cit-PABMonomethyl;Vat-Cit-PAB-Monomethyl Dolastatin 10;L-Valinamide, N-methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-;4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-3-methoxy-1-((R)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate
CBNumber: CB83363724
Molecular Formula: C60H93N11O11S
Formula Weight: 1176.51
MOL File: 1415329-13-3.mol

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VAL-CIT-PAB-MMAD Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0104956
Product name: Vat-Cit-PAB-MonomethylDolastatin10
Packaging: 10mg
Price: $2299
Updated: 2021/12/16

ChemScene

Product number: CS-0104956
Product name: Vat-Cit-PAB-MonomethylDolastatin10
Packaging: 25mg
Price: $4598
Updated: 2021/12/16

ChemScene

Product number: CS-0104956
Product name: Vat-Cit-PAB-MonomethylDolastatin10
Packaging: 50mg
Price: $8046
Updated: 2021/12/16

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VAL-CIT-PAB-MMAD Chemical Properties,Usage,Production

Uses

Vat-Cit-PAB-Monomethyl Dolastatin 10 is a agent-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.

IC 50

Auristatin

References

[1] Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9. DOI:10.1038/nchem.2415

VAL-CIT-PAB-MMAD Preparation Products And Raw materials

Raw materials

Preparation Products

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VAL-CIT-PAB-MMAD Suppliers

China 11 United States 4 Global 15

Beijing Jin Ming Biotechnology Co., Ltd.

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Heze Development Zone chuangli Chemical Co., Ltd.

Tel: 0530-+86-530-529 6766，+86-15666160102 15666160102
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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Beijing Jin Ming Biotechnology Co., Ltd.

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Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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Biosynth Biological Technology (Suzhou) Co Ltd

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1415329-13-3, VAL-CIT-PAB-MMADRelated Search:

VAL-CIT-PAB-MMAD

Vat-Cit-PAB-MMAD

Vat-Cit-PAB-Monomethyl Dolastatin 10

Vat-Cit-PABMonomethyl

L-Valinamide, N-methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-

4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-3-methoxy-1-((R)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate

1415329-13-3

C60H93N11O11S