ChemicalBook > CAS DataBase List > CysLT1 Antagonist Q8
CysLT1 Antagonist Q8
- Product Name
- CysLT1 Antagonist Q8
- CAS No.
- 1541762-55-3
- Chemical Name
- CysLT1 Antagonist Q8
- Synonyms
- Q8 hydrochloride;CysLT1 Antagonist Q8;Q8 hydrochloride,Q-8 hydrochloride
- CBNumber
- CB83364110
- Molecular Formula
- C17H14ClNO2
- Formula Weight
- 299.75
- MOL File
- 1541762-55-3.mol
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CysLT1 Antagonist Q8 Chemical Properties,Usage,Production
Description
Q8 is a novel cysteinyl leukotreine receptor antagonist, inhibiting VEGF-independent angiogenesis and exerting an additive anti-angiogenic response with bevacizumab.
Uses
Q8, an effective antiangiogenic drug, is a CysLt1 antagonist (IC50 of 4.9 μM). Q8 is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF[1].
References
[1] Clare T Butler, et al. A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab. J Biol Chem. 2017 Mar 3;292(9):3552-3567. DOI:10.1074/jbc.M116.747766
CysLT1 Antagonist Q8 Preparation Products And Raw materials
Raw materials
Preparation Products
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CysLT1 Antagonist Q8 Suppliers
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