ChemicalBook > CAS DataBase List > (S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol

(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol

Product Name
(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol
CAS No.
1637542-33-6
Chemical Name
(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol
Synonyms
M-3814;Nedisertib;Peposertib;MSC2490484A;M-3814(nedisertib);Nedisertib (M3814);M3814 (MSC2490484A);Nedisertib (M3814) ，S8586;Nedisertib (M3814, MSC2490484A);MSC2490484A; MSC-2490484A; MSC 2490484A; M3814; M-3814; M 3814; NEDISERTIB
CBNumber
CB83364433
Molecular Formula
C24H21ClFN5O3
Formula Weight
481.91
MOL File
1637542-33-6.mol
More
Less

(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Property

Melting point:
>198°C (dec.)
Boiling point:
716.0±60.0 °C(Predicted)
Density 
1.405±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)
pka
11.35±0.20(Predicted)
form 
Solid
color 
Pale Yellow to Light Green
InChIKey
MOWXJLUYGFNTAL-FKEMPHOKNA-N
SMILES
[C@H](C1=CC(C2=C3C(=NC=N2)C=C(N2CCOCC2)C=C3)=C(F)C=C1Cl)(C1=NN=C(OC)C=C1)O |&1:0,r|
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28405
Product name
M3814
Packaging
1mg
Price
$69
Updated
2021/12/16
Cayman Chemical
Product number
28405
Product name
M3814
Packaging
10mg
Price
$483
Updated
2021/12/16
Cayman Chemical
Product number
28405
Product name
M3814
Packaging
5mg
Price
$259
Updated
2021/12/16
TRC
Product number
M199265
Product name
M-3814
Packaging
5mg
Price
$325
Updated
2021/12/16
TRC
Product number
M199265
Product name
M-3814
Packaging
1mg
Price
$100
Updated
2021/12/16
More
Less

(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Chemical Properties,Usage,Production

Uses

M-3814 is a reagent used in the preparation of serine/threonine protein kinase inhibitors useful for the treatment of cancer.

in vivo

In combination with IR, Nedisertib shows efficacy in all of the 6 mouse models of human cancer. In all models, a dose of 2 Gy administered daily for 1 week in combination with Nedisertib induces statically significant tumor growth inhibition compare to IR alone. Nedisertib, alone or in combination with IR, does not induce significant weight loss or visual signs of toxicity in the mice in any study[1].

IC 50

DNA-PK: <3 nM (IC50)

(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Suppliers

China 70 United States 3 Global 73
SuZhou GoodChemTech Co., Ltd
Tel
18136139868; 18136139868
Email
jinlun@goodchemtech.cn
Country
China
ProdList
284
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
998
Advantage
58
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Country
China
ProdList
1250
Advantage
50
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62

1637542-33-6, (S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanolRelated Search:


  • (S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol
  • M-3814
  • MSC2490484A
  • Nedisertib
  • M3814 (MSC2490484A)
  • MSC2490484A; MSC-2490484A; MSC 2490484A; M3814; M-3814; M 3814; NEDISERTIB
  • M-3814(nedisertib)
  • 3-Pyridazinemethanol, α-[2-chloro-4-fluoro-5-[7-(4-morpholinyl)-4-quinazolinyl]phenyl]-6-methoxy-, (αS)-
  • Nedisertib (M3814, MSC2490484A)
  • Nedisertib (M3814)
  • (S)-{2-chloro-4-fluoro-5-[7-(morpholin-4-yl)quinazolin-4-yl]phenyl}(6-methoxypyridazin-3-yl)methanol
  • Peposertib
  • Nedisertib (M3814) ，S8586
  • 1637542-33-6