ChemicalBook > CAS DataBase List > 1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

Product Name
1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
CAS No.
1792180-79-0
Chemical Name
1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
Synonyms
(2R,5S)-Ritlecitinib;Ritlecitinib Impurity 13;2-Propen-1-one, 1-[(2R,5S)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-;1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
CBNumber
CB83367959
Molecular Formula
C15H19N5O
Formula Weight
285.34
MOL File
1792180-79-0.mol
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1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Property

Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO : 220 mg/mL (771.01 mM; Need ultrasonic)
pka
13.03±0.50(Predicted)
form 
Solid
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Chemical Properties,Usage,Production

Uses

(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68[1].

IC 50

JAK3: 144.8 nM (IC50)

References

[1] Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyr-rolo[2,3-d]pyridinyl acrylamides. US20150158864A1.

1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Suppliers

China 11 United States 2 Global 13
Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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+86-21-50462321
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han_yajun@dctc.daicel.com
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Shanghai Kewel Chemical Co., Ltd.
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021-64609169 18901607656
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021-64609160
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greensnown@163.com
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China
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TaiChem Taizhou Limited
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052386810091
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zcwy9518@yeah.net
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China
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Hubei Yangxin Medical Technology Co., Ltd.
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15374522761
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QQ:2853117752
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3003392093@yongstandards.com
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China
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10000
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Haiji Pharmaceutical Technology (Suzhou) Co., Ltd
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18012778619
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3394205705@qq.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
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18162595016; 18162595016
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3287908757@qq.com
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Cato Research Chemicals Inc.
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020-81960175-877 18933936954
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2853283383@qq.com
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1792180-79-0, 1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-oneRelated Search:


  • 1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
  • 2-Propen-1-one, 1-[(2R,5S)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-
  • (2R,5S)-Ritlecitinib
  • Ritlecitinib Impurity 13
  • 1792180-79-0