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ASTX660

Product Name: ASTX660
CAS No.: 1799328-86-1
Chemical Name: ASTX660
Synonyms: ASTX660;Tolinapant;ASTX660 (ASTX 660;ASTX660(Tolinapant）;Tolinapant (ASTX660);ASTX660, 10 mM in DMSO;Inhibitor,inhibit,ASTX-660,ASTX660,IAP,ASTX 660;1-(6-(4-Fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethanone;1-[6-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]ethanone;Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-
CBNumber: CB83368305
Molecular Formula: C30H42FN5O3
Formula Weight: 539.68
MOL File: 1799328-86-1.mol

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ASTX660 Property

Boiling point:: 716.6±60.0 °C(Predicted)
Density: 1.169±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:75.0(Max Conc. mg/mL);138.97(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);185.29(Max Conc. mM)
form: A solid
pka: 13.30±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BA166845
Product name: ASTX 660
Packaging: 10mg
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: 2550EF
Product name: 1-[6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methylmorpholin-4-yl]methyl]piperazin-1-yl]ethanone
Packaging: 10mg
Price: $434
Updated: 2021/12/16

DC Chemicals

Product number: DC20695
Product name: ASTX660(Tolinapant）
Purity: >98%
Packaging: 100mg
Price: $700
Updated: 2021/12/16

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ASTX660 Chemical Properties,Usage,Production

Uses

Tolinapant (ASTX660) is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).

in vivo

In HCC1806 xenografts in mice, Tolinapant (daily oral treatment) causes moderate tumor growth inhibition but not regression^[1].

References

[1] Tomoko Smyth, et al. Abstract 1287: The dual IAP antagonist, ASTX660, increases the anti-tumor activity of NSC 125973 in preclinical models of triple-negative breast cancer in vivo. Cancer Res 2016;76(14 Suppl).

ASTX660 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ASTX660 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: ASTX660 1799328-86-1
Price: US $0.00-0.00/MG
Min. Order: 1MG
Purity: 98
Supply Ability: 100G
Release date: 2024-04-17

1799328-86-1, ASTX660Related Search:

ASTX660 (ASTX 660

ASTX660

Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-

ASTX660(Tolinapant）

1-(6-(4-Fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethanone

Inhibitor,inhibit,ASTX-660,ASTX660,IAP,ASTX 660

Tolinapant

Tolinapant (ASTX660)

ASTX660, 10 mM in DMSO

1-[6-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]ethanone

1799328-86-1

C30H42FN5O3

API