Atogepant (MK-8031)

ChemicalBook > CAS DataBase List > Atogepant (MK-8031)

Product Name: Atogepant (MK-8031)
CAS No.: 1374248-81-3
Chemical Name: Atogepant (MK-8031)
Synonyms: MK-8031;Atogepant API;MK8031. Atogepant;Atogepant Monohydrate;(3'S)-1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-Spiro[6H-;(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamid;(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxamide;(3'S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide;Spiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide, 1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-, (3'S)-;(S)-1'-(tert-butyl)-N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
CBNumber: CB83368673
Molecular Formula: C29H23F6N5O3
Formula Weight: 603.52
MOL File: 1374248-81-3.mol

Less

Atogepant (MK-8031) Property

Boiling point:: 693.9±55.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 11.08±0.20(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Less

Atogepant (MK-8031) Chemical Properties,Usage,Production

Uses

Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.

Definition

ChEBI: Atogepant is a secondary carboxamide resulting from the formal condensation of the carboxy group of (3'S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid with the amino group of (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one. It is a selective oral, small-molecule antagonist of calcitonin gene-related peptide (CGRP) receptor that has been approved for the treatment of migraine. It has a role as a calcitonin gene-related peptide receptor antagonist. It is a secondary carboxamide, an azaspiro compound, an organic heterotetracyclic compound, a trifluorobenzene and a member of piperidones.

Mechanism of action

Atogepant (MK-8031) is an antagonist of the calcitonin gene-related peptide receptor. It competes with CGRP for occupancy at these receptors, preventing the actions of CGRP and its ability to induce and perpetuate migraine headache pain.

Atogepant (MK-8031) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Atogepant (MK-8031) Suppliers

China 46 India 1 United States 1 Global 48

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 5469
Advantage: 58

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 28-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 511
Advantage: 57

Anhui Lianchuang Biological Medicine Co.,Ltd

Tel: 0551-68779238 18056025720
Email: sales3@lcywhx.com
Country: China
ProdList: 168
Advantage: 57

Syncozymes (Shanghai) Co.,Ltd.

Tel: 021-68187180-819 13681683526
Fax: 021-68187179
Email: lchen@syncozymes.com
Country: China
ProdList: 191
Advantage: 55

Shanghai Pansopharm Technology Co., Ltd.

Tel: 021-20962833 15316628753
Fax: 021-2096-2832
Email: sales@pansopharm.com
Country: China
ProdList: 481
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
Country: China
ProdList: 595
Advantage: 55

Porton Pharma Solutions Ltd.

Tel: 23-86083200-6540
Fax: 023860832006830
Email: jia.chen@portonpharma.com
Country: China
ProdList: 56
Advantage: 58

Jinan Kabotang Biological Technology Co.,Ltd.

Tel: 0531-61320525 15866703830
Email: 495745175@qq.com
Country: China
ProdList: 6640
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 7019
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19105
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

Wuhan Demeikai Biotechnology Co., Ltd

Tel: +8618942921723
Email: info@dmksw.xin
Country: China
ProdList: 723
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6313
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-13773155751 19901447308
Email: 260924549@qq.com
Country: China
ProdList: 8742
Advantage: 58

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Country: China
ProdList: 5738
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 3689
Advantage: 58

nanjing dingda Pharmatech. co. ltd

Tel: 18013843276
Email: 1642441764@qq.com
Country: China
ProdList: 88
Advantage: 58

Suzhou Albertchem Co.,Ltd.

Tel: 0512-88968486 18012631750
Email: sales@albertchemical.com
Country: China
ProdList: 268
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 15229202216
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com
Country: China
ProdList: 18488
Advantage: 58

Pushan Industry (Shaanxi) Co., Ltd.

Tel: 029-81310890 13571859809
Email: info@pushanshiye.com
Country: China
ProdList: 10004
Advantage: 58

Hubei Aiputi Bioengineering Co., Ltd.

Tel: 17762444226
Email: d17762444226@163.com
Country: China
ProdList: 2402
Advantage: 58

Hubei Hicks Biochemical Co., Ltd

Tel: 17362916295; 17362916295
Email: w17362916295@163.com
Country: China
ProdList: 4054
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 5224
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 4164
Advantage: 58

Jinan Sanbao Biotechnology Co., Ltd.

Tel: 13854185395; 13854185395
Email: sanbaobiotech@126.com
Country: China
ProdList: 9375
Advantage: 58

Tianjin Hengze Pharmaceutical Technology Co. , Ltd.

Tel: 15822166320
Email: sales-tj@medhonor.com.cn
Country: China
ProdList: 126
Advantage: 58

Shandong Mopai Biotechnology Co., Ltd

Tel: 13053322091 13053322091
Email: admin@mopaikeji.com
Country: China
ProdList: 10974
Advantage: 58

Nantong Zhonghe Chemical New Materials Co., Ltd

Tel: 13003551299 13003551299
Email: 2369399482@qq.com
Country: China
ProdList: 7568
Advantage: 58

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2919
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5019
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Shaanxi Istare Biotechnology Co., Ltd.

Tel: 029-81530825 18682931470
Email: 2142355700@qq.com
Country: China
ProdList: 1454
Advantage: 58

Shanghai Yanze Chemical Co., Ltd

Tel: 021-13621551597 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 6455
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-18670069958 18670069958
Email: 184792226@qq.com
Country: China
ProdList: 3060
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9621
Advantage: 58

Wuhan Jingkang en Biomedical Technology Co., Ltd

Tel: +8613720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 4604
Advantage: 58

Changzhou AniKare Pharmatech Co., Ltd.

Tel: +86-0519-8359-8696 +8618018249389
Email: sales@anikare.com
Country: China
ProdList: 8472
Advantage: 58

SyncoZymes (Shanghai) Co., Ltd.,

Tel: +86-021-68187180-811 +86-13681683526
Fax: 012-68187179
Email: lchen@syncozymes.com
Country: China
ProdList: 188
Advantage: 58

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43348
Advantage: 58

shandong perfect biotechnology co.ltd

Tel: +86-53169958659; +8618596095638
Fax: 8653169958659
Email: sales@sdperfect.com
Country: China
ProdList: 294
Advantage: 58

Zibo Hangyu Biotechnology Development Co., Ltd

Tel: +86-0533-2185556 +8617865335152
Email: Mandy@hangyubiotech.com
Country: China
ProdList: 11013
Advantage: 58

Jiangsu shring Biopharma Co., Ltd.

Tel: +8613372282299
Email: sales@shringchem.com
Country: China
ProdList: 3545
Advantage: 58

Less

View Lastest Price from Atogepant (MK-8031) manufacturers

shandong perfect biotechnology co.ltd

Product: Atogepant 1374248-81-3
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 1kg
Release date: 2023-08-02

1374248-81-3, Atogepant (MK-8031)Related Search:

MK-8031

Spiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide, 1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-, (3'S)-

(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxamide

(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamid

MK8031. Atogepant

Atogepant API

(S)-1'-(tert-butyl)-N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide

(3'S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide

(3'S)-1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-Spiro[6H-

Atogepant Monohydrate

1374248-81-3

C29H23F6N5O3