ChemicalBook > CAS DataBase List > RP-5063

RP-5063

Product Name: RP-5063
CAS No.: 1239729-06-6
Chemical Name: RP-5063
Synonyms: RP5603;RP-5063;Brilaroxazine;Trolamine Impurity 11;Brilaroxazine, 10 mM in DMSO;2H-1,4-Benzoxazin-3(4H)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-;6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one;6-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydro-2H-1,4-benzoxazin-3-one;Dopamine Receptor,Parkinson,depressive,hypertension,cardiac,Brilaroxazine,RP 5063,syndrome,ADHD,autism,inhibit,Pulmonary,PAH,RP-5063,Serotonin Receptor,Alzheimer,5-HT Receptor,Inhibitor,disorder,Tourette,arterial,5-hydroxytryptamine Receptor
CBNumber: CB83372159
Molecular Formula: C22H25Cl2N3O3
Formula Weight: 450.36
MOL File: 1239729-06-6.mol

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RP-5063 Property

Boiling point:: 643.0±55.0 °C(Predicted)
Density: 1.301±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 100 mg/mL (222.04 mM; Need ultrasonic)
pka: 12.36±0.20(Predicted)
form: Solid
color: Off-white to light yellow
InChI: InChI=1S/C22H25Cl2N3O3/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20/h3-7,14H,1-2,8-13,15H2,(H,25,28)
InChIKey: PMKMNTBZJOXTJW-UHFFFAOYSA-N
SMILES: O1C2=CC=C(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)C=C2NC(=O)C1

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Hazard and Precautionary Statements (GHS)

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RP-5063 Chemical Properties,Usage,Production

Uses

Brilaroxazine was developed as a antipsychotic which may be effective in the treatment of schizophrenia and bipolar disorder.

in vivo

Brilaroxazine (oral gavage; 10 mg/kg; twice daily; 28 days) limits the functional and structural effects of pulmonary arterial hypertension (PAH), with significant improvements in pulmonary hemodynamics, right ventricular (RV) hypertrophy, SO2, and pulmonary blood vessel structural changes^[1].

Animal Model:	SD-rats^[2]
Dosage:	10 mg/kg
Administration:	Oral gavage; twice daily; 28 days
Result:	Had the efficacy in PAH, and mitigated the functional and structural effects of MCT-induced PAH.

IC 50

5-HT_1A Receptor: 1.5 nM (Ki); 5-HT_2A Receptor: 2.5 nM (Ki); 5-HT_2B Receptor: 0.19 nM (Ki); 5-HT₇ Receptor: 2.7 nM (Ki); D₂ Receptor; D₃ Receptor; D₄ Receptor

RP-5063 Preparation Products And Raw materials

Raw materials

Preparation Products

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RP-5063 Suppliers

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1239729-06-6, RP-5063Related Search:

RP-5063

Brilaroxazine

Dopamine Receptor,Parkinson,depressive,hypertension,cardiac,Brilaroxazine,RP 5063,syndrome,ADHD,autism,inhibit,Pulmonary,PAH,RP-5063,Serotonin Receptor,Alzheimer,5-HT Receptor,Inhibitor,disorder,Tourette,arterial,5-hydroxytryptamine Receptor

2H-1,4-Benzoxazin-3(4H)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-

6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one

6-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydro-2H-1,4-benzoxazin-3-one

Trolamine Impurity 11

RP5603

Brilaroxazine, 10 mM in DMSO

1239729-06-6

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