Azido-PEG3-Val-Cit-PAB-PNP
- Product Name
- Azido-PEG3-Val-Cit-PAB-PNP
- CAS No.
- 2055047-18-0
- Chemical Name
- Azido-PEG3-Val-Cit-PAB-PNP
- Synonyms
- Azido-PEG3-Val-Cit-PAB-PNP
- CBNumber
- CB83373570
- Molecular Formula
- C34H47N9O12
- Formula Weight
- 773.8
- MOL File
- 2055047-18-0.mol
Azido-PEG3-Val-Cit-PAB-PNP Property
- solubility
- Soluble in DMSO, DMF
- form
- Solid
- color
- White to light yellow
- InChIKey
- HLBCDJANEWKOSX-XIKWSGLJNA-N
- SMILES
- [C@@H](CCCNC(=O)N)(NC(=O)[C@H](C(C)C)NC(=O)CCOCCOCCOCCN=[N+]=[N-])C(=O)NC1C=CC(COC(=O)OC2C=CC(N(=O)=O)=CC=2)=CC=1 |&1:0,11,r|
N-Bromosuccinimide Price
- Product number
- BP-23368
- Product name
- Azido-PEG3-Val-Cit-PAB-PNP
- Purity
- 95%
- Packaging
- 100mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- CS-0114400
- Product name
- Azido-PEG3-Val-Cit-PAB-PNP
- Packaging
- 50mg
- Price
- $1250
- Updated
- 2021/12/16
- Product number
- CS-0114400
- Product name
- Azido-PEG3-Val-Cit-PAB-PNP
- Packaging
- 100mg
- Price
- $2050
- Updated
- 2021/12/16
Azido-PEG3-Val-Cit-PAB-PNP Chemical Properties,Usage,Production
Description
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. PNP groupg is a good leaving group when treating with aminebearing payload. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility.
Uses
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs; Protease Cleavable Linker; Cleavable Linker
References
[1] Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. DOI:10.3390/ph11020032
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG3-Val-Cit-PAB-PNP Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG3-Val-Cit-PAB-PNP manufacturers
- Product
- Azido-PEG3-Val-Cit-PAB-PNP 2055047-18-0
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >98.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-29