3-Bromo-5-(1,1-difluoro-ethyl)-pyridine
- Product Name
- 3-Bromo-5-(1,1-difluoro-ethyl)-pyridine
- CAS No.
- 1108724-32-8
- Chemical Name
- 3-Bromo-5-(1,1-difluoro-ethyl)-pyridine
- Synonyms
- 3-Bromo-5-(1,1-difluoro-ethyl)-pyridine;Pyridine, 3-bromo-5-(1,1-difluoroethyl)-
- CBNumber
- CB83376319
- Molecular Formula
- C7H6BrF2N
- Formula Weight
- 222.03
- MOL File
- 1108724-32-8.mol
3-Bromo-5-(1,1-difluoro-ethyl)-pyridine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C7H6BrF2N/c1-7(9,10)5-2-6(8)4-11-3-5/h2-4H,1H3
- InChIKey
- WHDYQJPECGZSLP-UHFFFAOYSA-N
- SMILES
- C1=NC=C(C(F)(F)C)C=C1Br
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 7987DT
- Product name
- 3-Bromo-5-(1,1-difluoroethyl)pyridine
- Packaging
- 100mg
- Price
- $211
- Updated
- 2021/12/16
- Product number
- A108735
- Product name
- 3-Bromo-5-(1,1-difluoroethyl)pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $373
- Updated
- 2021/12/16
- Product number
- CM247727
- Product name
- 3-Bromo-5-(1,1-difluoroethyl)pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $410
- Updated
- 2021/12/16
- Product number
- CD11351861
- Product name
- 3-Bromo-5-(1,1-difluoroethyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $434
- Updated
- 2021/12/16
- Product number
- 1108724328
- Product name
- 3-Bromo-5-(1,1-difluoroethyl)pyridine
- Packaging
- 1g
- Price
- $438
- Updated
- 2021/12/16
3-Bromo-5-(1,1-difluoro-ethyl)-pyridine Chemical Properties,Usage,Production
Synthesis
38940-62-4
1108724-32-8
General procedure for the synthesis of 3-bromo-5-(1,1-difluoroethyl)pyridine from 3-acetyl-5-bromopyridine: 1-(5-bromopyridin-3-yl)ethanone (500 mg, 2.5 mmol) and bis(2-methoxyethyl)aminosulfur trifluoride (BAST, 2.2 g, 10 mmol) were dissolved in dichloromethane (8 mL) in an airtight tube at 60 C overnight. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding reagent ratio PE:EtOAc = 1:1) and after confirming the completion of the reaction, the reaction mixture was concentrated. The residue was purified by fast column chromatography (silica gel as stationary phase, eluent ratio PE:EtOAc = 1:1) to afford the target product 3-bromo-5-(1,1-difluoroethyl)pyridine (200 mg, 36% yield). Mass spectrometry (MS) analysis showed (M + 1) = 222/224.
References
[1] Patent: WO2014/418, 2014, A1. Location in patent: Page/Page column 56
[2] Patent: US2015/197511, 2015, A1. Location in patent: Paragraph 0275; 0276
[3] Patent: WO2015/138220, 2015, A1. Location in patent: Page/Page column 87
3-Bromo-5-(1,1-difluoro-ethyl)-pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-5-(1,1-difluoro-ethyl)-pyridine Suppliers
- Tel
- 19829389091
- Fax
- QQ:399787610
- 399787610@qq.com
- Country
- China
- ProdList
- 2575
- Advantage
- 58
- Tel
- 19950139520
- cd_chemical@126.com
- Country
- China
- ProdList
- 300
- Advantage
- 56
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 029-86115547 17791676824
- Fax
- 021-51602123
- sales@cochemical.com
- Country
- China
- ProdList
- 4006
- Advantage
- 58
- Tel
- 0512-69561983 13914027025
- Fax
- 0512-69561982
- zhang_q@medinoah.com
- Country
- China
- ProdList
- 3811
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 0371-0371-55153829 18003835034
- 2853979819@qq.com
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 18992018580 18165105898
- Fax
- QQ:1617857088
- 13608210612@163.com
- Country
- China
- ProdList
- 2983
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58