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Evocalcet

Product Name
Evocalcet
CAS No.
870964-67-3
Chemical Name
Evocalcet
Synonyms
MT4580;MT 4580;Ivocase;Ivanka.;MT-4580;KHK7580;Evocalcet;Ivanka Sai;Evocalcet, 10 mM in DMSO;Calcium-sensing receptor,KHK-7580,Inhibitor,KHK 7580,CaSR,Evocalcet,inhibit
CBNumber
CB83384772
Molecular Formula
C24H26N2O2
Formula Weight
374.48
MOL File
870964-67-3.mol
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Evocalcet Property

Boiling point:
594.4±50.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:5.0(Max Conc. mg/mL);13.35(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);13.35(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.81(Max Conc. mM)
form 
A crystalline solid
pka
4.71±0.10(Predicted)
color 
White to off-white
InChI
InChI=1S/C24H26N2O2/c1-17(22-8-4-6-19-5-2-3-7-23(19)22)25-20-13-14-26(16-20)21-11-9-18(10-12-21)15-24(27)28/h2-12,17,20,25H,13-16H2,1H3,(H,27,28)/t17-,20+/m1/s1
InChIKey
RZNUIYPHQFXBAN-XLIONFOSSA-N
SMILES
C1(CC(O)=O)=CC=C(N2CC[C@H](N[C@@H](C3=C4C(C=CC=C4)=CC=C3)C)C2)C=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
N345665
Product name
4-[(3S)-3-[[(1R)-1-(1-Naphthalenyl)ethyl]amino]-1-pyrrolidinyl]benzeneaceticAcid
Packaging
25mg
Price
$725
Updated
2021/12/16
ChemScene
Product number
CS-0014698
Product name
Evocalcet
Purity
99.05%
Packaging
5mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-0014698
Product name
Evocalcet
Purity
99.05%
Packaging
10mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0014698
Product name
Evocalcet
Purity
99.05%
Packaging
50mg
Price
$450
Updated
2021/12/16
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Evocalcet Chemical Properties,Usage,Production

Uses

4-[(3S)-3-[[(1R)-1-(1-Naphthalenyl)ethyl]amino]-1-pyrrolidinyl]benzeneacetic Acid is part of a pharmaceutical composition that is a therapeutic agent for hyperparathyroidism.

in vivo

Evocalcet (0.03 or 0.3 mg/kg; oral Administration, once) affects serum PTH and Ca levels[1]. Evocalcet (0.3 mg/kg; oral Administration, once daily, for 5 weeks) reduces the serum PTH and Ca levels and increases the serum IP (inorganic phosphorus) level[1].

Animal Model:Male Sprague Dawley chronic kidney disease (CKD) rats with adenine induced secondary hyperparathyroidism (SHPT)[1]
Dosage:0.03 and 0.3 mg/kg
Administration:Oral Administration; 0.03 and 0.3 mg/kg, once
Result:Decreased the serum PTH and Ca levels at a dose of 0.3 mg/kg.

Evocalcet Preparation Products And Raw materials

Raw materials

Preparation Products

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Evocalcet Suppliers

China 99 India 1 United States 2 Global 102
Shengyang Runze (Beijing) Technology Co.,
Tel
010-010-57302162 17611011830
Email
lyt001@syrz01.com
Country
China
ProdList
169
Advantage
58
Nanjing Weiyuan Biomedical Co., Ltd.
Tel
17312961000
Email
syrz2020@gamil.com
Country
China
ProdList
32
Advantage
58
Nanjing JiuSiNuo Biopharmaceutical Technology Co., Ltd
Tel
18851976882
Email
chensheng870628@126.com
Country
China
ProdList
59
Advantage
58
Nanjing webright Pharmaceutical Technology Co., Ltd
Tel
18066048793; 18014498793
Email
1504914633@qq.com
Country
China
ProdList
1307
Advantage
58
Synthetics China Co.,Ltd
Tel
0512-65218020 18248732722
Email
biz@pharmsyn.com
Country
China
ProdList
99
Advantage
60
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
2247
Advantage
55
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1987
Advantage
55
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View Lastest Price from Evocalcet manufacturers

Guangzhou Tosun Pharmaceutical Ltd
Product
Evocalcet 870964-67-3
Price
US $0.00-0.00/kg
Min. Order
5kg
Purity
98%-102%
Supply Ability
200kg
Release date
2024-12-27
Shaanxi Dideu New Materials Co. Ltd
Product
Evocalcet 870964-67-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-11

870964-67-3, EvocalcetRelated Search:


  • Evocalcet
  • KHK7580
  • Benzeneacetic acid, 4-[(3S)-3-[[(1R)-1-(1-naphthalenyl)ethyl]amino]-1-pyrrolidinyl]-
  • 2-{4-[(3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}pyrrolidin-1-yl]phenyl}acetic acid
  • Calcium-sensing receptor,KHK-7580,Inhibitor,KHK 7580,CaSR,Evocalcet,inhibit
  • Ivocase
  • MT 4580
  • MT4580
  • MT-4580
  • Ivanka.
  • Evocalcet, 10 mM in DMSO
  • Ivanka Sai
  • 870964-67-3