Synta66

Product Name: Synta66
CAS No.: 835904-51-3
Chemical Name: Synta66
Synonyms: Synta66;Synta66, 10 mM in DMSO;N-(2',5'-Dimethoxy-[1,1'-biphenyl]-4-yl)-3-fluoroisonicotinamide;4-Pyridinecarboxamide, N-(2',5'-dimethoxy[1,1'-biphenyl]-4-yl)-3-fluoro-;inhibit,Ca2+ release-activated Ca2+ channels,Calcium release-activated channels,CRAC Channel,Inhibitor,Synta66,Synta 66,Synta-66
CBNumber: CB83384787
Molecular Formula: C20H17FN2O3
Formula Weight: 352.36
MOL File: 835904-51-3.mol

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Synta66 Property

storage temp.: Store at -20°C
solubility: DMSO : 77.5 mg/mL (219.95 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
color: White to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0034949
Product name: Synta66
Purity: 99.31%
Packaging: 5mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-0034949
Product name: Synta66
Purity: 99.31%
Packaging: 10mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-0034949
Product name: Synta66
Purity: 99.31%
Packaging: 25mg
Price: $650
Updated: 2021/12/16

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Synta66 Chemical Properties,Usage,Production

Description

Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease.

Synta66 is an inhibitor of Orai, which forms the pore of the CRAC channel. Synta66 (10 μM) attenuates peak SOCE in Müller glia. Synta66 (10 μM) prevents orai channels mediating the residual SOC current in Trpc1-/- Müller cells[1]. Synta66 (10 μM) nearly completely blocks the Ca2+ entry signal evoked by CaCl2 addition, whereas it moderately reduces Ca2+ mobilization from stores with 10% to 30% in platelet. Synta66 (10 μM) suppresses human platelet activation in plasma and whole-blood thrombus formation. Synta66 (10 μM) also inhibits murine platelet responses and thrombus formation[2]. Synta66 (10 μM) inhibits LAD2 human mast cell line. Synta66 (10 μM) significantly inhibits FcεRI stimulated histamine and TNFα secretion, and has differential effects on FcεRI stimulated prostaglandin D2 and cytokine release in human lung mast cells (HLMCs)[3].

References

[1]. Molnár T, et al. Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels. J Neurosci. 2016 Mar 16;36(11):3184-98. [2]. van Kruchten R, et al. Antithrombotic potential of blockers of store-operated calcium channels in platelets. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1717-23. [3]. Wajdner HE, et al. Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. Physiol Rep. 2017 Mar;5(5).

Synta66 Preparation Products And Raw materials

Raw materials

Preparation Products

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Synta66 Suppliers

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835904-51-3, Synta66Related Search:

Synta66

4-Pyridinecarboxamide, N-(2',5'-dimethoxy[1,1'-biphenyl]-4-yl)-3-fluoro-

inhibit,Ca2+ release-activated Ca2+ channels,Calcium release-activated channels,CRAC Channel,Inhibitor,Synta66,Synta 66,Synta-66

N-(2',5'-Dimethoxy-[1,1'-biphenyl]-4-yl)-3-fluoroisonicotinamide

Synta66, 10 mM in DMSO

835904-51-3