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OSW-1

Product Name
OSW-1
CAS No.
145075-81-6
Chemical Name
OSW-1
Synonyms
OSW-1;Orsaponin;OSW-1 (Orsaponin);OSW-1, >90% (Orsaponin);16beta-[2-O-Acetyl-3-O-[2-O-(4-Methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3b;(3β,16β)-16-[[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one;Cholest-5-en-22-one,16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-b-D-xylopyranosyl]-a-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3b,16b)-;Cholest-5-en-22-one, 16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3β,16β)-;16beta-[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3beta,17alpha-dihydroxycholest-5-en-22-one;(2S,3R,4S,5R)-2-{[(2S,3R,4S,5S)-2-{[(1S,2S,3aS,3bR,7S,9aR,9bS,11aS)-1,7-dihydroxy-9a,11a-dimethyl-1-[(2S)-6-methyl-3-oxoheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-2-yl]oxy}-3-(acetyloxy)-5-hydroxyoxan-4-yl]oxy}-4,5-dihydroxyoxan-3-yl 4-methoxybenzoate
CBNumber
CB8339904
Molecular Formula
C47H68O15
Formula Weight
873.03
MOL File
145075-81-6.mol
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OSW-1 Property

Boiling point:
932.5±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
pka
12.65±0.70(Predicted)
form 
Solid
color 
White to Off-White
InChIKey
MPXTYZZFIJTPPA-GMJJYARYNA-N
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30310
Product name
OSW-1
Packaging
1mg
Price
$452
Updated
2024/03/01
Cayman Chemical
Product number
30310
Product name
OSW-1
Packaging
5mg
Price
$947
Updated
2024/03/01
Cayman Chemical
Product number
30310
Product name
OSW-1
Packaging
500μg
Price
$238
Updated
2024/03/01
TRC
Product number
O703583
Product name
OSW-1,>90%(Orsaponin)
Packaging
2.5mg
Price
$910
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1053098
Product name
OSW-1
Purity
95.00%
Packaging
5MG
Price
$801.71
Updated
2021/12/16
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OSW-1 Chemical Properties,Usage,Production

Description

OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities. It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with Ki values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates. It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells. OSW-1 inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM. It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus. It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM. OSW-1 inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively).

Uses

OSW-1 is a unique steroidal saponin displaying selective cytotoxicity against cancer cell lines. From Ornithogalum Saundersiae bulbs.

in vivo

To ascertain whether or not OSW-1 is as effective in vivo, a nude mouse model inoculated by LoVo cells is adopted, in which OSW-1 treatment is performed when tumors became palpable. The results show that the size of tumors in treated mice is smaller on average than control mice. The significant difference is observed from the 15-17 th day following treatment, and this difference is gradually increased until the animals are sacrificed. Compared with the control group, the tumor weight of the OSW-1-treated group significantly decreases (P<0.05). Additionally, no apparent side effects are observed in OSW-1-treated mice. These results demonstrate that OSW-1 has powerful effects on suppressing colon tumor growth without significant side effects in vivo[2].

References

[1] YOSHIHIRO MIMAKI ?. Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs[J]. Bioorganic & Medicinal Chemistry Letters, 1997, 7 5: Pages 633-636. DOI: 10.1016/s0960-894x(97)00071-1
[2] BRETT L. ROBERTS . Differing activities of oxysterol-binding protein (OSBP) targeting anti-viral compounds[J]. Antiviral research, 2019, 170: Article 104548. DOI: 10.1016/j.antiviral.2019.104548
[3] ANTHONY W G BURGETT. Natural products reveal cancer cell dependence on oxysterol-binding proteins[J]. Nature chemical biology, 2011, 7 9: 639-647. DOI: 10.1038/nchembio.625
[4] LUCIAN ALBULESCU . Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP[J]. Antiviral research, 2015, 117: Pages 110-114. DOI: 10.1016/j.antiviral.2015.02.013
[5] JEROEN R P M STRATING. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.[J]. Cell reports, 2015, 10 4: 600-615. DOI: 10.1016/j.celrep.2014.12.054

OSW-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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OSW-1 Suppliers

China 43 United States 7 Global 50
Shanghai ruichang pharmaceutical technology co., LTD
Tel
18621054990
Email
maychemicals@sina.com
Country
China
ProdList
673
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
998
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Chemleader Biomedical Co., Limited.
Tel
021-58180488
Fax
021-58180499
Email
sales@MedChemLeader.com
Country
China
ProdList
1006
Advantage
58
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View Lastest Price from OSW-1 manufacturers

Career Henan Chemica Co
Product
OSW-1 145075-81-6
Price
US $8.00/KG
Min. Order
1g
Purity
Min98% HPLC/GC
Supply Ability
g/kg/ton
Release date
2020-10-27

145075-81-6, OSW-1Related Search:

OSW-1 ZK-134306

  • 16beta-[2-O-Acetyl-3-O-[2-O-(4-Methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3b
  • 16beta-[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3beta,17alpha-dihydroxycholest-5-en-22-one
  • (3β,16β)-16-[[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one
  • OSW-1
  • OSW-1 (Orsaponin)
  • Cholest-5-en-22-one, 16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3β,16β)-
  • OSW-1, >90% (Orsaponin)
  • Cholest-5-en-22-one,16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-b-D-xylopyranosyl]-a-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3b,16b)-
  • Orsaponin
  • (2S,3R,4S,5R)-2-{[(2S,3R,4S,5S)-2-{[(1S,2S,3aS,3bR,7S,9aR,9bS,11aS)-1,7-dihydroxy-9a,11a-dimethyl-1-[(2S)-6-methyl-3-oxoheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-2-yl]oxy}-3-(acetyloxy)-5-hydroxyoxan-4-yl]oxy}-4,5-dihydroxyoxan-3-yl 4-methoxybenzoate
  • 145075-81-6
  • C47H68O15