ODZXEQVQLJKSQH-UHFFFAOYSA-N

Product Name: ODZXEQVQLJKSQH-UHFFFAOYSA-N
CAS No.: 1010100-22-7
Chemical Name: ODZXEQVQLJKSQH-UHFFFAOYSA-N
Synonyms: ODZXEQVQLJKSQH-UHFFFAOYSA-N;Thalidomide-5-CH2-NH2 (hydrochloride);5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, HCl salt;5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochlorde;5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride;5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride;1H-Isoindole-1,3(2H)-dione, 5-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
CBNumber: CB83402940
Molecular Formula: C14H14ClN3O4
Formula Weight: 323.73
MOL File: 1010100-22-7.mol

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ODZXEQVQLJKSQH-UHFFFAOYSA-N Property

storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A1215841
Product name: 5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dionehydrochloride
Purity: 97%
Packaging: 100mg
Price: $253
Updated: 2021/12/16

Ambeed

Product number: A1215841
Product name: 5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dionehydrochloride
Purity: 97%
Packaging: 250mg
Price: $390
Updated: 2021/12/16

Ambeed

Product number: A1215841
Product name: 5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dionehydrochloride
Purity: 97%
Packaging: 1g
Price: $1053
Updated: 2021/12/16

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ODZXEQVQLJKSQH-UHFFFAOYSA-N Chemical Properties,Usage,Production

Uses

Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs[1].

IC 50

Cereblon

References

[1] Makbul C, Nassal M, B?ttcher B. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14. DOI:10.7554/eLife.57277
[2] Sato T, Ito T, Handa H. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326

ODZXEQVQLJKSQH-UHFFFAOYSA-N Preparation Products And Raw materials

Raw materials

Preparation Products

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ODZXEQVQLJKSQH-UHFFFAOYSA-N Suppliers

China 30 United States 1 Global 31

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1010100-22-7, ODZXEQVQLJKSQH-UHFFFAOYSA-NRelated Search:

ODZXEQVQLJKSQH-UHFFFAOYSA-N

1H-Isoindole-1,3(2H)-dione, 5-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride

5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride

Thalidomide-5-CH2-NH2 (hydrochloride)

5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, HCl salt

5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochlorde

1010100-22-7