1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Property

storage temp. 

-20°C

solubility 

DMSO: 1mg/mL

form 

lyophilized solid

color 

white

Safety

WGK Germany 

WGK 1

Storage Class

11 - Combustible Solids

Hazard and Precautionary Statements (GHS)

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Chemical Properties,Usage,Production

Uses

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.
A cell-permeable, potent, selective, reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM.

Biological Activity

Cell permeable: yes', 'Primary Target
Cathepsin K', 'Product does not compete with ATP.', 'Reversible: yes', 'Target Ki: 9.7 nM against cathepsin K