2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- Product Name
- 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- CAS No.
- 54135-60-3
- Chemical Name
- 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- Synonyms
- M50054;M50054, 10 mM in DMSO;Apoptosis Inhibitor (M50054);M 50054, apoptosis inhibitor;2,2-METHYLENEBIS-(1,3-CYCLOHEXANEDIONE);2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE);2,2'-METHYLENE BIS CYCLOHEXANE-1,3-DIONE;1,3-Cyclohexanedione, 2,2'-methylenebis-;Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem;2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione
- CBNumber
- CB8363800
- Molecular Formula
- C13H16O4
- Formula Weight
- 236.26
- MOL File
- 54135-60-3.mol
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Property
- Melting point:
- 132.5-133.5 °C
- Boiling point:
- 461.2±40.0 °C(Predicted)
- Density
- 1.227±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO or ethanol
- form
- Off-white solid
- pka
- 4.87±0.25(Predicted)
- color
- off-white
- Sensitive
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- R750778
- Product name
- 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- 178488
- Product name
- Apoptosis Inhibitor
- Packaging
- 10mg
- Price
- $146
- Updated
- 2025/07/31
- Product number
- R750778
- Product name
- 2,2''-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 20810
- Product name
- M50054
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20810
- Product name
- M50054
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Chemical Properties,Usage,Production
Uses
A cell-permeable inhibitor of apoptosis induction. Inhibits caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
Definition
ChEBI: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione is a beta-diketone.
Biological Activity
m50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]in human fas-expressing wc8 cells, m50054 inhibited apoptosis by soluble human fas ligand in vitro cell death assay. m50054 inhibited the apoptotic u937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. m50054 inhibited apoptotic characters such as dna phosphatidylserine and fragmentation exposure in these cells. these anti-apoptotic effects were dependent on inhibition of caspase-3 activation. additionally, m50054 significantly inhibited anti-fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. alopecia (hair loss) symptoms were also significantly improved with topical treatment with m50054. m50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1]
in vivo
M50054 (10-300 mg/kg; oral administration 30 min before anti-Fas antibody injection) inhibits the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner[1].
M50054 (topical treatment; given daily beginning on day 5 after birth and ending on day 14) significantly improves alopecia (hair loss) symptoms[1].
| Animal Model: | Female BALB/c mice[1] |
| Dosage: | 10, 30, 100 or 300 mg/kg |
| Administration: | Orally administered in a volume of 10 mL/kg |
| Result: | Inhibited the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner. Significantly improved these parameters at doses of 100 mg/kg and 300 mg/kg. |
| Animal Model: | Five-day-old SD rats[1] |
| Dosage: | |
| Administration: | Topically applied to the head and back of 5-day-old rats once daily for 10 days |
| Result: | Alopecia scores significantly decreased throughout the entire observation period compared with the control group. |
target
Caspase
References
tsuda t, ohmori y, muramatsu h et al. inhibitory effect of m50054, a novel inhibitor of apoptosis, on anti-fas-antibody-induced hepatitis and chemotherapy-induced alopecia.eur j pharmacol. 2001 dec 14;433(1):37-45.
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Preparation Products And Raw materials
Raw materials
Preparation Products
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