2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- Product Name
- 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- CAS No.
- 54135-60-3
- Chemical Name
- 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- Synonyms
- M50054;2,2-METHYLENEBIS-(1,3-CYCLOHEXANEDIONE);2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE);2,2'-METHYLENE BIS CYCLOHEXANE-1,3-DIONE;1,3-Cyclohexanedione, 2,2'-methylenebis-;Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem;2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione;Apoptosis,Alopecia,Hepatitis,chemotherapy,Inhibitor,M50054,Caspase-3,Etoposide,Fas,M-50054,anti-Fas,M 50054,inhibit
- CBNumber
- CB8363800
- Molecular Formula
- C13H16O4
- Formula Weight
- 236.26
- MOL File
- 54135-60-3.mol
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Property
- Melting point:
- 132.5-133.5 °C
- Boiling point:
- 461.2±40.0 °C(Predicted)
- Density
- 1.227±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO or ethanol
- form
- Off-white solid
- pka
- 4.87±0.25(Predicted)
- Sensitive
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- R750778
- Product name
- 2,2''-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 178488
- Product name
- Apoptosis Inhibitor
- Packaging
- 10mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- J65036
- Product name
- M50054
- Packaging
- 10mg
- Price
- $121
- Updated
- 2021/12/16
- Product number
- 20810
- Product name
- M50054
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20810
- Product name
- M50054
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Chemical Properties,Usage,Production
Uses
A cell-permeable inhibitor of apoptosis induction. Inhibits caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
Definition
ChEBI: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione is a beta-diketone.
Biological Activity
m50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]in human fas-expressing wc8 cells, m50054 inhibited apoptosis by soluble human fas ligand in vitro cell death assay. m50054 inhibited the apoptotic u937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. m50054 inhibited apoptotic characters such as dna phosphatidylserine and fragmentation exposure in these cells. these anti-apoptotic effects were dependent on inhibition of caspase-3 activation. additionally, m50054 significantly inhibited anti-fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. alopecia (hair loss) symptoms were also significantly improved with topical treatment with m50054. m50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1]
target
Caspase
References
tsuda t, ohmori y, muramatsu h et al. inhibitory effect of m50054, a novel inhibitor of apoptosis, on anti-fas-antibody-induced hepatitis and chemotherapy-induced alopecia.eur j pharmacol. 2001 dec 14;433(1):37-45.
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Preparation Products And Raw materials
Raw materials
Preparation Products
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