ChemicalBook > CAS DataBase List > 2-(TRICHLOROACETYL)PYRROLE

2-(TRICHLOROACETYL)PYRROLE

Product Name
2-(TRICHLOROACETYL)PYRROLE
CAS No.
35302-72-8
Chemical Name
2-(TRICHLOROACETYL)PYRROLE
Synonyms
2,2,2-TRICHLORO-1-(1H-PYRROL-2-YL)ETHAN-1-ONE;2,2,2-TRICHLORO-1-(1H-PYRROL-2-YL)ETHANONE;NSC 272669;LABOTEST-BB LT00452244;trichloroacetyl)pyrrole;2-(TRICHLOROACETYL)PYRROLE;2-(Trichloroacetyl)-pyrrol;2-(Trichloroacetyl)-1H-pyrr;2-(Trichloroacetyl)-1H-pyrrole;2-PYRROLYL TRICHLOROMETHYL KETONE
CBNumber
CB8365400
Molecular Formula
C6H4Cl3NO
Formula Weight
212.46
MOL File
35302-72-8.mol
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2-(TRICHLOROACETYL)PYRROLE Property

Melting point:
72-74 °C (lit.)
Boiling point:
285℃
Density 
1.591
Flash point:
126℃
storage temp. 
2-8°C
solubility 
Chloroform, Methanol
form 
Powder
pka
14.18±0.50(Predicted)
color 
Pale gray
CAS DataBase Reference
35302-72-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36/37//38
Safety Statements 
26-36
RIDADR 
UN 1759 8/PG III
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
395137
Product name
2-(Trichloroacetyl)pyrrole
Purity
99%
Packaging
10g
Price
$39.7
Updated
2025/07/31
Sigma-Aldrich
Product number
395137
Product name
2-(Trichloroacetyl)pyrrole
Purity
99%
Packaging
50g
Price
$150.63
Updated
2025/07/31
TCI Chemical
Product number
T1619
Product name
2-(Trichloroacetyl)pyrrole
Purity
>98.0%(GC)
Packaging
5g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
T1619
Product name
2-(Trichloroacetyl)pyrrole
Purity
>98.0%(GC)
Packaging
25g
Price
$84
Updated
2025/07/31
TRC
Product number
T774085
Product name
2-(Trichloroacetyl)pyrrole
Packaging
5g
Price
$220
Updated
2021/12/16
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2-(TRICHLOROACETYL)PYRROLE Chemical Properties,Usage,Production

Uses

2-(Trichloroacetyl)pyrrole, is a building block used for the synthesis of more complex pharmaceutical compounds, such as Oroidin, Hymenidin and Clathrodin.

General Description

2-(Trichloroacetyl)pyrrole is a 2-substituted pyrrole. It undergoes acylation to afford 4-acyl derivatives (4-formyl to 4-hexanoyl).

Synthesis

109-97-7

76-02-8

35302-72-8

To a stirred solution of 2,2,2-trichloroacetyl chloride (25.5 mL, 0.227 mol) in anhydrous ether (45 mL) was added pyrrole (14.3 mL, 0.206 mol) slowly and dropwise at 0°C in an ice bath. The reaction mixture was stirred continuously. After the reaction was carried out for 2 days, brine solution (300 mL) was added to the reaction solution. Subsequently, the mixture was extracted with ethyl acetate (3 x 100 mL) and water (100 mL). The organic extracts were combined, dried with anhydrous magnesium sulfate (MgSO?), and then evaporated to remove the solvent to afford the target product 2,2,2-trichloro-1-(1H-pyrrol-2-yl)ethanone as a brown solid (43.6 g, 99% yield).

References

[1] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 897 - 905
[2] Journal of Organic Chemistry, 1993, vol. 58, # 25, p. 7245 - 7257
[3] Tetrahedron Letters, 2014, vol. 55, # 49, p. 6698 - 6702
[4] Patent: EP3248968, 2017, A1. Location in patent: Paragraph 0097
[5] Organic Letters, 2011, vol. 13, # 17, p. 4550 - 4553

2-(TRICHLOROACETYL)PYRROLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(TRICHLOROACETYL)PYRROLE Suppliers

China 165 France 2 Germany 3 India 11 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 18 Global 211
Specs
Tel
--
Fax
--
Email
info@specs.net
Country
The Netherlands
ProdList
6833
Advantage
70
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View Lastest Price from 2-(TRICHLOROACETYL)PYRROLE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-(TRICHLOROACETYL)PYRROLE 35302-72-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-16
Career Henan Chemical Co
Product
2-(TRICHLOROACETYL)PYRROLE 35302-72-8
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

35302-72-8, 2-(TRICHLOROACETYL)PYRROLERelated Search:

2-(TRICHLOROACETYL)PYRROLE 2,2,2-TRICHLORO-1-[4-(4-CHLOROBENZOYL)-1H-PYRROL-2-YL]-1-ETHANONE 2,2,2-TRICHLORO-1-[4-(2,4-DICHLOROBENZOYL)-1H-PYRROL-2-YL]-1-ETHANONE 1-[5-(2,2,2-TRICHLOROACETYL)-1H-PYRROL-3-YL]-1-PROPANONE 2-TRICHLOROACETYL-1-METHYLPYRROLE 2-([1-METHYL-5-(2,2,2-TRICHLOROACETYL)-1H-PYRROL-3-YL]CARBONYL)BENZENECARBOXYLIC ACID 2,2,2-TRICHLORO-1-[4-(2-PHENYLACETYL)-1H-PYRROL-2-YL]-1-ETHANONE 2-(Trichloroacetyl)pyrrole-4-sulfonyl chloride 4-NITRO-2-(TRICHLOROACETYL)-PYRROLE 4-IODO-2-(TRICHLOROACETYL)PYRROLE 2,2,2-TRICHLORO-1-(4-[(5-METHYL-3-PHENYL-4-ISOXAZOLYL)CARBONYL]-1H-PYRROL-2-YL)-1-ETHANONE 2,2,2-TRICHLORO-1-[4-(2-CHLOROBENZOYL)-1H-PYRROL-2-YL]-1-ETHANONE 2,2,2-TRICHLORO-1-(4-[2-FLUORO-4-(TRIFLUOROMETHYL)BENZOYL]-1H-PYRROL-2-YL)-1-ETHANONE 2,2,2-TRICHLORO-1-(4-[4-(TRIFLUOROMETHYL)BENZOYL]-1H-PYRROL-2-YL)-1-ETHANONE 2,2,2-TRICHLORO-1-(4-[2-(TRIFLUOROMETHYL)BENZOYL]-1H-PYRROL-2-YL)-1-ETHANONE 1-[4-(2-BROMOBENZOYL)-1H-PYRROL-2-YL]-2,2,2-TRICHLORO-1-ETHANONE 4-[1-METHYL-5-(2,2,2-TRICHLOROACETYL)-1H-PYRROL-3-YL]-4-OXO-2-BUTENOIC ACID 2,2,2-TRICHLORO-1-(4-[(3-CHLORO-2-THIENYL)CARBONYL]-1H-PYRROL-2-YL)-1-ETHANONE

  • LABOTEST-BB LT00452244
  • 2-(TRICHLOROACETYL)PYRROLE
  • 2-PYRROLYL TRICHLOROMETHYL KETONE
  • 2,2,2-TRICHLORO-1-(1H-PYRROL-2-YL)ETHAN-1-ONE
  • 2,2,2-TRICHLORO-1-(1H-PYRROL-2-YL)ETHANONE
  • 2-(Trichloroacetyl)-1H-pyrrole
  • NSC 272669
  • trichloroacetyl)pyrrole
  • 2-(Trichloroacetyl)-pyrrol
  • Ethanone, 2,2,2-trichloro-1-(1H-pyrrol-2-yl)-
  • 2-(Trichloroacetyl)-1H-pyrr
  • 1-(1H-Pyrrol-2-yl)-2,2,2-trichloroethan-1-one, 2-(2,2,2-Trichloroethanoyl)-1H-pyrrole
  • 2-Trichloroacetyl chloride pyrrole
  • 35302-72-8
  • C6H4Cl3NO
  • Pyrroles
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Building Blocks
  • Pyrroles & Indoles
  • Azoles
  • blocks
  • Carboxes
  • Pyrroles & Indoles