3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE

Product Name: 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE
CAS No.: 19881-70-0
Chemical Name: 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE
Synonyms: 104523;Windorphen;SALOR-INT L161004-1EA;Windorphen >=98% (HPLC);Windorphen - CAS 19881-70-0 - Calbiochem;3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrolein;3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)prop-2-enal;(Z)-3-chloro-2,3-bis(4-Methoxyphenyl)acrylaldehyde
CBNumber: CB8372871
Molecular Formula: C17H15ClO3
Formula Weight: 302.75
MOL File: 19881-70-0.mol

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3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Property

Melting point:: 160-163°C
Boiling point:: 468.1±45.0 °C(Predicted)
Density: 1.198±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.09164
Product name: Windorphen - CAS 19881-70-0 - Calbiochem
Packaging: 25mg
Price: $225
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML0899
Product name: Windorphen
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $111
Updated: 2022/05/15

TRC

Product number: W498903
Product name: Windorphen
Packaging: 500g
Price: $360
Updated: 2021/12/16

Matrix Scientific

Product number: 045974
Product name: 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
Purity: >95%
Packaging: 5g
Price: $500
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC136063
Product name: 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
Packaging: 5G
Price: $578
Updated: 2021/12/16

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3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Chemical Properties,Usage,Production

Uses

Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates with?β-catenin,?blocking the Wnt signal required for ventral development.

Biological Activity

windorphen is a wnt inhibitor that selectively abrogates the wnt signaling for ventral development.wnt protein is a family of signaling proteins that interacts on the wnt/β-catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.in canonical wnt/β-catenin reporter cell line stf293, windorphen dose-dependently inhibits wnt3a-inducible topflash-luciferase activity (ic50 of 1.5 mm). in human colon adenocarcinomasw480 cells with defective apc gene that constitutively activates wnt signaling, 72 h treatment of windorphen causes a wide spread apoptosis. [1]in zebrafish embryos, windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). windorphen selectively inhibits wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). in addition, windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective axin1/β-catenin destruction complex causes abnormal activation of wnt signaling and the loss of telencephalon and eyes.) [1]

References

1. hao j, ao a, zhou l et al. selective small molecule targeting β-catenin function discovered by invivo chemical genetic screen. cell rep. 2013 sep 12;4(5):898-904.

3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Suppliers

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19881-70-0, 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDERelated Search:

3-chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde oxime AURORA KA-5407 RARECHEM AL BF 1128 AURORA KA-3545 AURORA KA-5341 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE RARECHEM AL BI 1128 AURORA KA-5629

SALOR-INT L161004-1EA

Windorphen - CAS 19881-70-0 - Calbiochem

104523

3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE

3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE

Windorphen

(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrolein

(Z)-3-chloro-2,3-bis(4-methoxyphenyl)prop-2-enal

(Z)-3-chloro-2,3-bis(4-Methoxyphenyl)acrylaldehyde

Benzeneacetaldehyde, α-[chloro(4-methoxyphenyl)methylene]-4-methoxy-, (αZ)-

Windorphen >=98% (HPLC)

Benzeneacetaldehyde, α-[chloro(4-methoxyphenyl)methylene]-4-methoxy-, (αZ)-

19881-70-0

C17H15ClO3