3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE
- Product Name
- 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE
- CAS No.
- 19881-70-0
- Chemical Name
- 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE
- Synonyms
- 104523;Windorphen;SALOR-INT L161004-1EA;Windorphen >=98% (HPLC);Windorphen - CAS 19881-70-0 - Calbiochem;3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrolein;3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)prop-2-enal;(Z)-3-chloro-2,3-bis(4-Methoxyphenyl)acrylaldehyde
- CBNumber
- CB8372871
- Molecular Formula
- C17H15ClO3
- Formula Weight
- 302.75
- MOL File
- 19881-70-0.mol
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Property
- Melting point:
- 160-163°C
- Boiling point:
- 468.1±45.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
- HazardClass
- IRRITANT
N-Bromosuccinimide Price
- Product number
- 5.09164
- Product name
- Windorphen - CAS 19881-70-0 - Calbiochem
- Packaging
- 25mg
- Price
- $225
- Updated
- 2023/01/07
- Product number
- SML0899
- Product name
- Windorphen
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $111
- Updated
- 2022/05/15
- Product number
- W498903
- Product name
- Windorphen
- Packaging
- 500g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 045974
- Product name
- 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
- Purity
- >95%
- Packaging
- 5g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- FC136063
- Product name
- 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
- Packaging
- 5G
- Price
- $578
- Updated
- 2021/12/16
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Chemical Properties,Usage,Production
Uses
Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates with?β-catenin,?blocking the Wnt signal required for ventral development.
Biological Activity
windorphen is a wnt inhibitor that selectively abrogates the wnt signaling for ventral development.wnt protein is a family of signaling proteins that interacts on the wnt/β-catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.in canonical wnt/β-catenin reporter cell line stf293, windorphen dose-dependently inhibits wnt3a-inducible topflash-luciferase activity (ic50 of 1.5 mm). in human colon adenocarcinomasw480 cells with defective apc gene that constitutively activates wnt signaling, 72 h treatment of windorphen causes a wide spread apoptosis. [1]in zebrafish embryos, windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). windorphen selectively inhibits wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). in addition, windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective axin1/β-catenin destruction complex causes abnormal activation of wnt signaling and the loss of telencephalon and eyes.) [1]
References
1. hao j, ao a, zhou l et al. selective small molecule targeting β-catenin function discovered by invivo chemical genetic screen. cell rep. 2013 sep 12;4(5):898-904.
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Preparation Products And Raw materials
Raw materials
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