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TAPI-2

Product Name
TAPI-2
CAS No.
187034-31-7
Chemical Name
TAPI-2
Synonyms
TAPI-2;CS-2628;TAPI2;TAPI 2;TNF Protease Inhibitor 2;TNF-ALPHA PROTEASE INHIBITOR-2;TAPI-2, MMP and ADAM inhibitor;TAPI-2 (TNF Protease Inhibitor 2);HONHCOCH2CH(CH2-CH(CH3)2)CO-T-LEU-ALA-NHCH2CH2NH2;N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-T-BUTYL-GLYCYL-L-ALANINE 2-AMINOETHYL AMIDE;N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-T-BUTYL-ALANYL-L-ALANINE, 2-AMINOETHYL AMIDE
CBNumber
CB8374178
Molecular Formula
C19H37N5O5
Formula Weight
415.53
MOL File
Mol file
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TAPI-2 Property

Density 
1.127±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Ethanol: 5 mg/ml; Water: 8 mg/ml
form 
Solid
pka
9.17±0.20(Predicted)
color 
White to off-white
Sensitive 
Light Sensitive & Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
579052
Product name
TAPI-2 - CAS 187034-31-7 - Calbiochem
Packaging
1mg
Price
$488
Updated
2025/07/31
Sigma-Aldrich
Product number
5.09612
Product name
InSolution TAPI-2 - CAS 187034-31-7 - Calbiochem
Packaging
1mg
Price
$504
Updated
2025/07/31
Cayman Chemical
Product number
14695
Product name
TAPI-2
Purity
≥95%
Packaging
500μg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
14695
Product name
TAPI-2
Purity
≥95%
Packaging
1mg
Price
$253
Updated
2024/03/01
Tocris
Product number
6013
Product name
TAPI2
Purity
≥95%(HPLC)
Packaging
1
Price
$288
Updated
2021/12/16
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TAPI-2 Chemical Properties,Usage,Production

Uses

N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide is a TACE inhibitor. Inhibits the secretase in pig kidney microvillar membranes.

Uses

A hydroxamate-based inhibitor of MMPs and TACE

Definition

ChEBI: N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid is a dipeptide.

Biological Activity

Cell permeable: no', 'Primary Target
MMPs', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 18 μM against angiotensin converting enzyme

IC 50

MMP: 20 μM (IC50)

TAPI-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAPI-2 Suppliers

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187034-31-7, TAPI-2Related Search:

GLYCYL-L-ALANINE

  • TAPI-2
  • N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-T-BUTYL-ALANYL-L-ALANINE, 2-AMINOETHYL AMIDE
  • N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-T-BUTYL-GLYCYL-L-ALANINE 2-AMINOETHYL AMIDE
  • TNF-ALPHA PROTEASE INHIBITOR-2
  • HONHCOCH2CH(CH2-CH(CH3)2)CO-T-LEU-ALA-NHCH2CH2NH2
  • N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
  • N-[2-[2-(HydroxyaMino)-2-oxoethyl]-4-Methyl-1-oxopentyl]-3-Methyl-L-valyl-N-(2-aMinoethyl)-L-alaninaMide Acetic Acid
  • TAPI-2 (TNF Protease Inhibitor 2)
  • CS-2628
  • TAPI2;TAPI 2
  • TNF Protease Inhibitor 2
  • L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-
  • N1-((S)-1-(((S)-1-((2-Aminoethyl)amino)-1-oxopropan-2-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
  • N-[(1S)-1-{[(1S)-1-[(2-aminoethyl)carbamoyl]ethyl]carbamoyl}-2,2-dimethylpropyl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
  • TAPI-2, MMP and ADAM inhibitor
  • 187034-31-7
  • C19H37N5O5
  • A hydroxamate-based inhibitor of MMPs and TACE.