ECHINOCYSTIC ACID

Product Name: ECHINOCYSTIC ACID
CAS No.: 510-30-5
Chemical Name: ECHINOCYSTIC ACID
Synonyms: (3B2;16B1;(3u0003B2;16u0003B1;Echinocystic;Albizziagenin;Echicystic acid;lancemaside acid;ECHINOCYSTIC ACID;Echinocystic acid-RM
CBNumber: CB8379128
Molecular Formula: C30H48O4
Formula Weight: 472.7
MOL File: 510-30-5.mol

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ECHINOCYSTIC ACID Property

Melting point:: 299-300°C
Boiling point:: 585.0±50.0 °C(Predicted)
Density: 1.14
storage temp.: 2-8°C
solubility: DMF:30.0(Max Conc. mg/mL);63.46(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.7(Max Conc. mM)
form: powder
pka: 4.43±0.70(Predicted)
color: White
InChIKey: YKOPWPOFWMYZJZ-XVTBUTEGNA-N
SMILES: [C@@]12(CCC(C)(C)C[C@@]1([H])C1=CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)C[C@H]2O)C(=O)O |&1:0,7,12,14,18,23,27,29,32,r|
LogP: 7.580 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML4110
Product name: Echinocystic Acid
Purity: ≥97%
Packaging: 1 unit
Price: $75.05
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00505
Product name: Echinocystic acid
Purity: ≥95%
Packaging: 5MG
Price: $91.6
Updated: 2022/05/15

TCI Chemical

Product number: E1319
Product name: Echinocystic Acid
Packaging: 25MG
Price: $285
Updated: 2025/07/31

Cayman Chemical

Product number: 27476
Product name: Echinocystic Acid
Packaging: 10mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 27476
Product name: Echinocystic Acid
Packaging: 100mg
Price: $879
Updated: 2024/03/01

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ECHINOCYSTIC ACID Chemical Properties,Usage,Production

Description

Echinocystic acid is a triterpene that has been found in G. sinensis and has diverse biological activities. It induces nuclear translocation of the glucocorticoid receptor (GR) and reduces TNF-α-induced NF-κB signaling in HEK293 cells overexpressing GFP-GR. Echinocystic acid (12.5, 25, and 50 μM) suppresses RANKL-induced NF-κB activation, ERK phosphorylation, and osteoclastogenesis in mouse bone marrow macrophages (BMMs). It induces neurite outgrowth in Neuro2A cells in a concentration-dependent manner, an effect that can be blocked by the JNK inhibitor SP 600125 . In vivo, echinocystic acid (10 mg/kg per day) decreases escape latency in the Morris water maze and increases the length of neurite processes in the hippocampus of aged mice. Topical administration of echinocystic acid reduces expression of COX-2, inducible nitric oxide synthase (iNOS), TNF-α, and IL-1β and ear edema induced by phorbol 12-myristate 13-acetate (TPA; ) in a mouse model of dermatitis. Echinocystic acid also recovers reductions in femoral bone mineral density and trabecular thickness and number in a rat model of ovariectomy-induced osteoporosis.

Chemical Properties

White powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the soap horn, legumes from the acacia Albizzia julibrissin Durazz. inflorescences, pig's tooth soap.

Uses

Echinocystic Acid is a potential entry inhibitor for the HCV infection.

Definition

ChEBI: Echinocystic acid is a triterpenoid.

in vivo

Echinocystic acid (5 mg/kg intragastrically daily for 5 days) shows anti-depression activities in the mouse model of reserpine-induced pain-depression dyad^[2].

Animal Model:	Male adult C57BL/6 mice (8-10 week old; 18 to 22 g) injected weith Reserpine^[2]
Dosage:	5 mg/kg
Administration:	Intragastrically; daily for 5 days
Result:	Attenuated reserpine-induced pain/depression dyad partially through regulating the biogenic amines levels and GluN2B receptors in the hippocampus.

References

[1] DEMETRA GEORGATZA . The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists[J]. International Journal of Biochemistry & Cell Biology, 2016, 79: Pages 277-287. DOI: 10.1016/j.biocel.2016.08.028
[2] JIAN-HUI YANG . Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways[J]. Biochemical and biophysical research communications, 2016, 477 4: Pages 673-677. DOI: 10.1016/j.bbrc.2016.06.118
[3] HYE JIN PARK. Echinocystic Acid Facilitates Neurite Outgrowth in Neuroblastoma Neuro2a Cells and Enhances Spatial Memory in Aged Mice.[J]. Biological & pharmaceutical bulletin, 2017, 40 10: 1724-1729. DOI: 10.1248/bpb.b17-00324
[4] EUN-HA JOH Dong H K Jin Ju Jeong. Inhibitory effect of echinocystic acid on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice[J]. Archives of Pharmacal Research, 2013, 37 2: 225-231. DOI: 10.1007/s12272-013-0092-8
[5] YA-TING DENG. Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats.[J]. PLoS ONE, 2015: e0136572. DOI: 10.1371/journal.pone.0136572

ECHINOCYSTIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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ECHINOCYSTIC ACID Suppliers

China 212 Germany 2 India 2 United Kingdom 6 United States 21 Global 243

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

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View Lastest Price from ECHINOCYSTIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: ECHINOCYSTIC ACID 510-30-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Echinocystic Acid 510-30-5
Price: US $200.00-85.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-23

Shanghai Standard Technology Co., Ltd.

Product: Echinocystic acid 510-30-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-14

510-30-5, ECHINOCYSTIC ACIDRelated Search:

4-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID CIS-9-HENEICOSENE 2-BUTYL-2-ETHYL-1,3-PROPANEDIOL ECHINOCYSTIC ACID 3-Methyl-1-butanol 2-Propylpentanoic acid TRANS-9-OCTADECENOL ECHINOCYSTIC ACID-3-GLUCOSIDE,ECHINOCYSTIC ACID-3-O-GLUCOSIDE,ECHINOCYSTIC ACID-3-O-GLUCOSIDE WITH HPLC CAULOPHYLLOGENIN 4-BUTYLCYCLOHEXANE CARBOXYLIC ACID 2-Methyl-2-propyl-1,3-propanediol 2-HYDROXYCYCLOHEXANECARBOXYLIC ACID PENTASACCHARIDE OF ECHINOCYSTIC ACID 2-ETHYLNONANOIC ACID 2-(1,1-dimethylethyl)-4-methylcyclohexan-1-ol MYRISTELAIDIC ACID 3-HYDROXYHEXADECANOIC ACID 6,6-DIMETHYLHEPTANOIC ACID

ECHINOCYSTIC ACID

3-B,16-A-DIHYDROXYOLEAN-12-EN-28-OIC ACID

3BETA,16ALPHA-DIHYDROXY-OLEAN-12-EN-28-OIC ACID

(3beta,16alpha)-3,16-dihydroxyolean-12-en-28-oic acid

Echinocystic

ECHINOCYSTIC ACID(SH)

ECHINOCYSTIC ACID hplc

Echinocystic acid 510-30-5

(4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

ECHINOCYSTIC ACID WITH HPLC

3β,16α-Dihydroxy-5α-oleana-12-ene-28-oic acid

3β,16α-Dihydroxyolean-12-en-28-oic acid

Echicystic acid

Albizziagenin

Echinocystic acid, 98%, from Hedera Linn.

ECHINOCYSTIC ACID USP/EP/BP

(3B2

(3u0003B2

)-3,16-dihydroxyolean-12-en-28-oic acid

16B1

16u0003B1

Echinocystic acid (6CI)

Olean-12-en-28-oic acid, 3,16-dihydroxy-, (3β,16α)-

Echinocystic acid in methanol

Echinocystic acid-RM

(3β,16α)-3,16-dihydroxyolean-12-en-28-oic acid

lancemaside acid

510-30-5

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Tri-Terpenoids

Inhibitors