CASPASE-1 INHIBITOR TFA SALT

Product Name: CASPASE-1 INHIBITOR TFA SALT
CAS No.: 210345-00-9
Chemical Name: CASPASE-1 INHIBITOR TFA SALT
Synonyms: Z-WEHD-FMK-TFA;CASPASE-1 INHIBITOR TFA SALT;Caspase-1/ICE Inhibitor Z-WEHD-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA;Z-WE(OME)HD(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE;N-[(Phenylmethoxy)carbonyl]-L-tryptophyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-histidinamide methyl ester;L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester (9CI)
CBNumber: CB8382359
Molecular Formula: C37H42FN7O10
Formula Weight: 763.77
MOL File: 210345-00-9.mol

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CASPASE-1 INHIBITOR TFA SALT Property

Boiling point:: 1129.2±65.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥26.32 mg/mL in EtOH with ultrasonic; ≥46.33 mg/mL in DMSO
form: Powder
pka: 11.06±0.46(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A1924
Product name: Z-WEHD-FMK
Packaging: 5mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002128
Product name: CASPASE-1 INHIBITOR TFA SALT
Purity: 95.00%
Packaging: 5MG
Price: $505.63
Updated: 2021/12/16

ChemScene

Product number: CS-0018267
Product name: Z-WEHD-FMK
Purity: 98.64%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

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CASPASE-1 INHIBITOR TFA SALT Chemical Properties,Usage,Production

Biological Activity

treatment of infected cells with pan-caspase inhibitor iv and z-wehd-fmk, an inhibitor of inflammatory caspases, elicited a near-complete blockage of c. trachomatis-induced cleavage of golgin-84. golgin-84 cleavage was blocked via treatment of infected cells with z-wehd-fmk, resulting in a lack of golgi fragmentation and a 2-log reduction in numbers of infectious bacteria.we treated infected cells with z-wehd-fmk, effectively preventing golgi fragmentation, or with dmso as a control and then labelled cells with fluorescent ceramide. confocal images revealed that ceramide was rapidly incorporated into the inclusion membrane within dmso-treated cells and accumulated inside the inclusion in bacterial membranes. in contrast, z-wehd-fmk-treated cells were only slightly fluorescent as the majority of lipid accumulated in a golgi-like structure outside the inclusion1.general caspase inhibitor (z-asp-chz-dcb) and capase-5 inhibitor (z-wehd-fmk) could not induce rrna fragmentation treated with ecyd. caspase-5 (icerei ill/ty), member of ice protease, activated pathway may be concerned with ecyd induced rrna fragmentation2.

target

caspase-5

References

1. d. heuer, a.r. lipinski et al. chlamydia causes fragmentation of the golgi compartment to ensure reproduction. nature, 457, 2009 2. kamada, s., funahashi, y. and tsujimoto, y.(1997) cell death diff. 4, 473-478.

CASPASE-1 INHIBITOR TFA SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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CASPASE-1 INHIBITOR TFA SALT Suppliers

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210345-00-9, CASPASE-1 INHIBITOR TFA SALTRelated Search:

Z-TRP-NH2 Z-TRP-NHME CASPASE-1 INHIBITOR TFA SALT Carbobenzoxy-D,L-tryptophanamide

CASPASE-1 INHIBITOR TFA SALT

Z-WEHD-FMK-TFA

Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA

N-[(Phenylmethoxy)carbonyl]-L-tryptophyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-histidinamide methyl ester

Caspase-1/ICE Inhibitor Z-WEHD-FMK

Z-WE(OME)HD(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE

L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester (9CI)

210345-00-9

C37H42FN7O10

Apoptosis