ChemicalBook > CAS DataBase List > E-4031

E-4031

Product Name
E-4031
CAS No.
113559-13-0
Chemical Name
E-4031
Synonyms
E-4031;E4031 diHCl;E-4031 (hydrochloride);E-4031 dihydrochloride, HERG K+ channel blocker;1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb;Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG;N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid
CBNumber
CB8384065
Molecular Formula
C21H33Cl2N3O5S
Formula Weight
510.47
MOL File
113559-13-0.mol
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E-4031 Property

storage temp. 
-20°C
solubility 
H2O: soluble
form 
solid
color 
off-white
Stability:
Hygroscopic
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M5060
Product name
E-4031
Purity
≥98% (HPLC), lyophilized powder
Packaging
0.1mg
Price
$264
Updated
2024/03/01
Sigma-Aldrich
Product number
M5060
Product name
E-4031
Purity
≥98% (HPLC), lyophilized powder
Packaging
0.5mg
Price
$458.4
Updated
2024/03/01
Cayman Chemical
Product number
15203
Product name
E-4031 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
15203
Product name
E-4031 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$143
Updated
2024/03/01
Sigma-Aldrich
Product number
M5060
Product name
E-4031
Purity
≥98% (HPLC), solid
Packaging
1mg
Price
$1340
Updated
2024/03/01
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E-4031 Chemical Properties,Usage,Production

Uses

E-4031 has been used as:

  • human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
  • IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
  • IKr blocker in rat ventricular myocytes

Biological Activity

Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.

Biochem/physiol Actions

E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.

storage

Room temperature (desiccate)

E-4031 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-4031 Suppliers

China 59 Germany 3 Japan 1 Switzerland 1 United Kingdom 4 United States 16 Global 84
J & K SCIENTIFIC LTD.
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View Lastest Price from E-4031 manufacturers

Career Henan Chemical Co
Product
E-4031 113559-13-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-13

113559-13-0, E-4031Related Search:

N-Methylbenzylamine N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE 4-BENZOYLPIPERIDINE HYDROCHLORIDE Betahistine dihydrochloride N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE E-4031,E-4031 DIHYDROCHLORIDE 4-(4-PIPERIDINYLMETHYL)-BENZENAMINE 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE E-4031 2-(2'-AMINOETHYL)-6-METHYLPYRIDINE RARECHEM AL F1 4031 AURORA KA-4031 RARECHEM AK PP 4031 AKOS BB-4031 AURORA 4031 E-4031, Voltage-Gated (HERG) K+ Channel Blocker, 510.48MW

  • 1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined
  • methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb
  • E-4031
  • N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
  • N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid
  • E-4031 (hydrochloride)
  • N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL
  • N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride
  • Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG
  • E4031 diHCl
  • Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-, hydrochloride (1:2)
  • E-4031 dihydrochloride, HERG K+ channel blocker
  • 113559-13-0
  • C21H27N3O3S2HCl
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Monovalent Ion Channels
  • Ion Channels
  • Potassium Channel Modulators
  • Voltage-gated Ion Channels
  • BioChemical
  • Potassium channel
  • Ion Channels