(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE
- Product Name
- (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE
- CAS No.
- 403-32-7
- Chemical Name
- (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE
- Synonyms
- NSC 402742;4-FLUOROPHENYLGLYOXAL;(p-Fluorophenyl)glyoxal;4-Fluoro-α-oxo-benzeneacetaldehyde;(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE;Benzeneacetaldehyde, 4-fluoro-α-oxo-;4-fluoro-alpha-oxobenzeneacetaldehyde;4-fluoro-alpha-oxo-benzeneacetaldehyd;Benzeneacetaldehyde, 4-fluoro-.alpha.-oxo-;4-Fluoro-α-oxo-benzeneacetaldehyde, CAS 403-32-7
- CBNumber
- CB8388962
- Molecular Formula
- C8H5FO2
- Formula Weight
- 152.12
- MOL File
- 403-32-7.mol
(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE Property
- Melting point:
- 84-88℃
- Boiling point:
- 115℃/35mm
- Density
- 1.241±0.06 g/cm3(Predicted)
- RTECS
- CY1440000
- solubility
- Chloroform, Methanol
- form
- Solid
- color
- White
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Toxicity
- mouse,LD50,intraperitoneal,681mg/kg (681mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Journal of the Indian Chemical Society. Vol. 60, Pg. 369, 1983.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F595155
- Product name
- 4-Fluoro-α-oxo-benzeneacetaldehyde
- Packaging
- 50mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- F595155
- Product name
- 4-Fluoro-α-oxo-benzeneacetaldehyde
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- HCH0418082
- Product name
- 4-FLUORO-ALPHA-OXO-BENZENEACETALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.58
- Updated
- 2021/12/16
- Product number
- AH001299
- Product name
- 2-(4-Fluorophenyl)-2-oxoacetaldehyde
- Purity
- 95%
- Packaging
- 250mgs:
- Price
- $63.62
- Updated
- 2021/12/16
(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
4-Fluoro-α-oxo-benzeneacetaldehyde (cas# 403-32-7) is a compound useful in organic synthesis.
Synthesis
403-42-9
403-32-7
The general procedure for the synthesis of 4-fluorobenzoylformaldehyde from 4-fluoroacetophenone was as follows: selenium dioxide (6.70 g, 61.0 mmol) was added to a mixed solution of dioxane (100 mL) and water (3 mL) containing 4-fluoroacetophenone (8.43 g, 61.0 mmol). The resulting mixture was heated at 55 °C until selenium dioxide was completely dissolved. Subsequently, the reaction mixture was refluxed for 5 to 6 hours. After monitoring the completion of the reaction by thin layer chromatography (TLC), the mixture was filtered and the filtrate was concentrated under vacuum to obtain a viscous oily substance. Water (50 mL) was added to the oily substance and the resulting mixture was stirred for 12 hours. Afterwards, the solid formed was collected on a filter, washed with water (25 mL) and dried under vacuum to finally obtain 4-fluorophenylglyoxal (6.60 g, 85% yield).1H NMR (400 MHz, CDCl3) δ: 7.18 (m, 2H), 8.11 (d, 2H), no signal for aldehyde CHO was observed.
References
[1] Patent: WO2011/95625, 2011, A1. Location in patent: Page/Page column 94
[2] Tetrahedron Letters, 2017, vol. 58, # 7, p. 658 - 662
[3] Patent: WO2007/39821, 2007, A2. Location in patent: Page/Page column 16
[4] Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1651 - 1653
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 36, p. 10890 - 10894
(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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