2,5-Dibromobenzoic acid
- Product Name
- 2,5-Dibromobenzoic acid
- CAS No.
- 610-71-9
- Chemical Name
- 2,5-Dibromobenzoic acid
- Synonyms
- 5-DibroMobenzoic acid;2,5-dibromo-benzoicaci;2,5-DIBROMOBENZOIC ACID;Dapagliflozin Impurity P;2,5-DibroMobenyoic, Acid;2,5-DibromobenzoicAcid>2,5- twobroMo benzoic acid;2,5-Dibromobenzoicacid,95%;Benzoic acid, 2,5-dibromo-;Dapagliflozin Impurity N15
- CBNumber
- CB8394093
- Molecular Formula
- C7H4Br2O2
- Formula Weight
- 279.91
- MOL File
- 610-71-9.mol
2,5-Dibromobenzoic acid Property
- Melting point:
- 156-159 °C(lit.)
- Boiling point:
- 344.6±32.0 °C(Predicted)
- Density
- 1.9661 (rough estimate)
- refractive index
- 1.4970 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.46±0.10(Predicted)
- color
- White to Yellow to Orange
- BRN
- 1868193
- InChI
- InChI=1S/C7H4Br2O2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)
- InChIKey
- SQQKOTVDGCJJKI-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(Br)=CC=C1Br
- CAS DataBase Reference
- 610-71-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,5-Dibromobenzoic acid(610-71-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D3439
- Product name
- 2,5-Dibromobenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $62
- Updated
- 2025/07/31
- Product number
- D3439
- Product name
- 2,5-Dibromobenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $190
- Updated
- 2025/07/31
- Product number
- D425690
- Product name
- 2,5-Dibromobenzoic Acid
- Packaging
- 25g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 2621-9-08
- Product name
- 2,5-Dibromobenzoic acid
- Packaging
- 5G
- Price
- $16
- Updated
- 2021/12/16
- Product number
- C902
- Product name
- 2,5-Dibromobenzoic Acid
- Packaging
- 5g
- Price
- $19
- Updated
- 2021/12/16
2,5-Dibromobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
off-white powder
Uses
2,5-Dibromobenzoic Acid is an intermediate used to prepare benzo[c]chromenone and benzo[c]chromene derivatives as estrogen β-receptor-selective agonists in comparison with effusol and estradiol. It is also used in the synthesis of aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Synthesis
88-65-3
610-71-9
First, sodium periodate solution was prepared: 4.3 g (19.9 mmol) of sodium periodate was dissolved in a solvent mixture of 30 mL of water and 18 mL of acetic acid. Subsequently, 10 g (49.7 mmol) of o-bromobenzoic acid and 5.1 g (49.7 mmol) of sodium bromide were added to the reaction flask with the above prepared sodium periodate solution. The reaction mixture was heated to 30°C, at which temperature 4.4 mL of concentrated sulfuric acid was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was raised to 50 °C and the reaction was kept at this temperature for 2-3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and poured into ice water to precipitate the solid product. The solid was collected by filtration and the filter cake was washed several times with cold water to give 11.9 g of 2,5-dibromobenzoic acid in 85.6% yield.
Purification Methods
Crystallise the acid from water or EtOH. [Beilstein 9 H 358, 9 I 147, 9 II 237, 9 III 1428, 9 IV 1027.]
References
[1] Patent: CN107954852, 2018, A. Location in patent: Paragraph 0029-0031
[2] Justus Liebigs Annalen der Chemie, 1891, vol. 266, p. 203
[3] Journal of the Indian Chemical Society, 1980, vol. 57, # 6, p. 640 - 642
2,5-Dibromobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dibromobenzoic acid manufacturers
- Product
- 2,5-Dibromobenzoic acid 610-71-9
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12