DNQX disodiumsalt
- Product Name
- DNQX disodiumsalt
- CAS No.
- 1312992-24-7
- Chemical Name
- DNQX disodiumsalt
- Synonyms
- sodium 6;3-bis(olate);DNQX Disodium;3-dione disodium salt;DNQX disodium salt, 10 mM in DMSO;SODIUM 6;7-DINITROQUINOXALINE-2;3-BIS(OLATE);6;7-DINITROQUINOXALINE-2;3-DIONE DISODIUM SALT;quinoxaline,inhibit,Inhibitor,iGluR,competitive,DNQX disodium salt,non-NMDA,Ionotropic glutamate receptors,nucleus,selective,FG 9041 disodium,thalamic,reticular
- CBNumber
- CB83959570
- Molecular Formula
- C8H5N4NaO6
- Formula Weight
- 276.14
- MOL File
- 1312992-24-7.mol
DNQX disodiumsalt Property
- storage temp.
- Store at -20°C
- solubility
- 5mg/mL in DMSO, 12mg/mL in DMF
- form
- solid
- color
- Brown
- Water Solubility
- Soluble in water (100mM)
N-Bromosuccinimide Price
- Product number
- D100113
- Product name
- DNQXDisodiumSalt
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D100113
- Product name
- DNQXDisodiumSalt
- Packaging
- 2.5mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- B5288
- Product name
- DNQXdisodiumsalt
- Packaging
- 50mg
- Price
- $471
- Updated
- 2021/12/16
- Product number
- DC10673
- Product name
- DNQXdisodiumsalt
- Purity
- >98%
- Packaging
- 1g
- Price
- $800
- Updated
- 2021/12/16
- Product number
- DC10673
- Product name
- DNQXdisodiumsalt
- Purity
- >98%
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
DNQX disodiumsalt Chemical Properties,Usage,Production
Description
DNQX Disodium is a water-soluble form of selective non-NMDA receptor antagonist DNQX.
Uses
DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].
in vivo
DNQX (FG 9041), a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex[3].
storage
Room temperature (desiccate)
References
[1] Honoré T, et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 1988;241(4866):701-703. DOI:10.1126/science.2899909
[2] Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010;103(4):1728-1734. DOI:10.1152/jn.00540.2009
[3] Sharp JW, et al. DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex. Brain Res. 1995;687(1-2):114-124. DOI:10.1016/0006-8993(95)00477-8
DNQX disodiumsalt Preparation Products And Raw materials
Raw materials
Preparation Products
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