ChemicalBook > CAS DataBase List > 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

Product Name
5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.
13599-12-7
Chemical Name
5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
Synonyms
SALOR-INT L250031-1EA;Ethyl 3-phenyl-5-pyrazole formate;3-phenypyrazole-5-ethyl carboxylate;Ethyl 3-phenylpyrazole-5-carboxylate;ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE;5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;5-phenyl-1(2)H-pyrazole-3-carboxylic acid ethyl ester;1H-pyrazole-5-carboxylic acid, 3-phenyl-, ethyl ester
CBNumber
CB8400284
Molecular Formula
C12H12N2O2
Formula Weight
216.24
MOL File
Mol file
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5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER Property

storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Appearance
Off-white to light yellow Solid
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Safety

Safety Statements 
24/25
HazardClass 
IRRITANT
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E926115
Product name
Ethyl3-phenylpyrazole-5-carboxylate
Packaging
250mg
Price
$55
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0003959
Product name
ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE
Purity
95.00%
Packaging
1G
Price
$221.55
Updated
2021/12/16
AK Scientific
Product number
6410AA
Product name
Ethyl3-phenyl-1H-pyrazole-5-carboxylate
Packaging
25g
Price
$342
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0003959
Product name
ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE
Purity
95.00%
Packaging
5G
Price
$1316.7
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0003959
Product name
ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE
Purity
95.00%
Packaging
10G
Price
$1905.75
Updated
2021/12/16
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5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

98-86-2

95-92-1

13599-12-7

A mixed solution of acetophenone (100 g) with diethyl oxalate (123 g) was added slowly and dropwise to a mixed system of potassium tert-butoxide (132 g) and tetrahydrofuran (600 mL), and the reaction was stirred at room temperature for 15 hours. Subsequently, acetic acid (119 mL) and hydrazine monohydrate (45.8 g) were added to the reaction system and stirred at reflux for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature and concentrated under reduced pressure. The concentrated residue was dissolved in a solvent mixture of water and ethyl acetate for partition extraction. The ethyl acetate layer was separated, washed sequentially with saturated aqueous sodium carbonate and saturated saline, dried over anhydrous magnesium sulfate and concentrated. The resulting crude product was recrystallized by diisopropyl ether to give ethyl 3-phenyl-1H-pyrazole-5-carboxylate (145 g, yield: brown solid). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 1.36 (3H, t, J = 7.2 Hz), 4.36 (2H, q, J = 7.2 Hz), 7.10 (1H, s), 7.30-7.46 (3H, m), 7.71-7.80 (2H, m), 11.86 (1H, br s).

References

[1] Patent: WO2007/18314, 2007, A2. Location in patent: Page/Page column 115

5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Ethanol Hydrazine sulfate Diethyl oxalate Sodium Acetophenone

Preparation Products

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13599-12-7, 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTERRelated Search:

4-PHENYLPYRAZOLE 1-(4-CHLOROPHENYL)-3-HYDROXY-1H-PYRAZOLE

  • SALOR-INT L250031-1EA
  • 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
  • ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE
  • 1H-pyrazole-5-carboxylic acid, 3-phenyl-, ethyl ester
  • Ethyl 3-phenylpyrazole-5-carboxylate
  • Ethyl 3-phenyl-5-pyrazole formate
  • 5-phenyl-1(2)H-pyrazole-3-carboxylic acid ethyl ester
  • 3-phenypyrazole-5-ethyl carboxylate
  • 13599-12-7