ChemicalBook > CAS DataBase List > Zuranolone

Zuranolone

Product Name
Zuranolone
CAS No.
1632051-40-1
Chemical Name
Zuranolone
Synonyms
Zuranolone;SAGE-217;217;1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile;lygtf;CS-2797;Zuranolone, SAGE-217;Zuranolone SAGE-217 CS-2797;SAGE-217; SAGE 217; SAGE217;1632051-40-1;1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-
CBNumber
CB84033495
Molecular Formula
C25H35N3O2
Formula Weight
409.57
MOL File
1632051-40-1.mol
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Zuranolone Property

Boiling point:
574.3±30.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 10 mg/ml
form 
A crystalline solid
pka
15.17±0.60(Predicted)
InChIKey
HARRKNSQXBRBGZ-BOBURQISNA-N
SMILES
C[C@]12CC[C@]3([H])[C@@]4([H])CC[C@](O)(C)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@@H]2C(=O)CN1N=CC(C#N)=C1 |&1:1,4,6,10,14,18,20,24,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0023489
Product name
Zuranolone
Purity
99.96%
Packaging
2mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0023489
Product name
Zuranolone
Purity
99.96%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0023489
Product name
Zuranolone
Purity
99.96%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0023489
Product name
Zuranolone
Purity
99.96%
Packaging
25mg
Price
$320
Updated
2021/12/16
ChemScene
Product number
CS-0023489
Product name
Zuranolone
Purity
99.96%
Packaging
50mg
Price
$545
Updated
2021/12/16
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Zuranolone Chemical Properties,Usage,Production

Uses

Zuranolone is a potent GABAA receptor agonist.

Definition

Zuranolone is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor-positive modulator, and the first oral medication indicated to treat postpartum depression in adults 2.

Mechanism of action

The mechanism of action of zuranolone in treating PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABAA receptors. Unlike benzodiazepines, another class of GABAA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABAA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABAA receptors, composed of 2α2βγ subunits, and extrasynaptic GABAA receptors, composed of 2α2βδ subunits.

Zuranolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Zuranolone Suppliers

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View Lastest Price from Zuranolone manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Zuranolone 1632051-40-1
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-24

1632051-40-1, ZuranoloneRelated Search:


  • lygtf
  • SAGE-217
  • 217
  • SAGE-217; SAGE 217; SAGE217;1632051-40-1
  • CS-2797
  • Zuranolone
  • 1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile
  • 1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-
  • Inhibitor,inhibit,γ-Aminobutyric acid Receptor,Gamma-aminobutyric acid Receptor,GABA Receptor,Zuranolone
  • Zuranolone, SAGE-217
  • 1-(2-((3R,5R,8R,9R,10S,13S,14S,17S)-3-Hydroxy-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)-1H-pyrazole-4-carbonitrile
  • Zuranolone SAGE-217 CS-2797
  • 1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-
  • 1632051-40-1