Zuranolone
- Product Name
- Zuranolone
- CAS No.
- 1632051-40-1
- Chemical Name
- Zuranolone
- Synonyms
- Zuranolone;SAGE-217;217;1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile;lygtf;CS-2797;Zuranolone, SAGE-217;Zuranolone SAGE-217 CS-2797;SAGE-217; SAGE 217; SAGE217;1632051-40-1;1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-
- CBNumber
- CB84033495
- Molecular Formula
- C25H35N3O2
- Formula Weight
- 409.57
- MOL File
- 1632051-40-1.mol
Zuranolone Property
- Boiling point:
- 574.3±30.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 10 mg/ml
- form
- A crystalline solid
- pka
- 15.17±0.60(Predicted)
- InChIKey
- HARRKNSQXBRBGZ-BOBURQISNA-N
- SMILES
- C[C@]12CC[C@]3([H])[C@@]4([H])CC[C@](O)(C)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@@H]2C(=O)CN1N=CC(C#N)=C1 |&1:1,4,6,10,14,18,20,24,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- CS-0023489
- Product name
- Zuranolone
- Purity
- 99.96%
- Packaging
- 2mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-0023489
- Product name
- Zuranolone
- Purity
- 99.96%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0023489
- Product name
- Zuranolone
- Purity
- 99.96%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0023489
- Product name
- Zuranolone
- Purity
- 99.96%
- Packaging
- 25mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- CS-0023489
- Product name
- Zuranolone
- Purity
- 99.96%
- Packaging
- 50mg
- Price
- $545
- Updated
- 2021/12/16
Zuranolone Chemical Properties,Usage,Production
Uses
Zuranolone is a potent GABAA receptor agonist.
Definition
Zuranolone is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor-positive modulator, and the first oral medication indicated to treat postpartum depression in adults 2.
Mechanism of action
The mechanism of action of zuranolone in treating PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABAA receptors. Unlike benzodiazepines, another class of GABAA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABAA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABAA receptors, composed of 2α2βγ subunits, and extrasynaptic GABAA receptors, composed of 2α2βδ subunits.
Zuranolone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Zuranolone manufacturers
- Product
- Zuranolone 1632051-40-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-07-24