5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide

Product Name: 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide
CAS No.: 1421701-68-9
Chemical Name: 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide
Synonyms: Biotin-PEG3-Alkyne;Propargyl-PEG3-Biotin;N-(2-(2-(2-(prop-2-ynyloxy)ethoxy)ethoxy)ethyl)-5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanamide;1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]ethyl]-, (3aS,4S,6aR)-;5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide
CBNumber: CB84034351
Molecular Formula: C19H31N3O5S
Formula Weight: 413.53
MOL File: 1421701-68-9.mol

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5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide Property

Boiling point:: 687.3±55.0 °C(Predicted)
Density: 1.163±0.06 g/cm3(Predicted)
pka: 13.90±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide Chemical Properties,Usage,Production

Uses

Biotin-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide Suppliers

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1421701-68-9, 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamideRelated Search:

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)pentanamide

Biotin-PEG3-Alkyne

1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]ethyl]-, (3aS,4S,6aR)-

N-(2-(2-(2-(prop-2-ynyloxy)ethoxy)ethoxy)ethyl)-5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Propargyl-PEG3-Biotin

1421701-68-9

C19H31N3O5S

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