N-Hydroxybenzenecarboximidoyl chloride
- Product Name
- N-Hydroxybenzenecarboximidoyl chloride
- CAS No.
- 698-16-8
- Chemical Name
- N-Hydroxybenzenecarboximidoyl chloride
- Synonyms
- -Chlorobenzaldoxime;A-CHLOROBENZALDOXIME;o-Chlorobenzaldoxime;α-Chlorobenzaldoxime;Cloxacillin Impurity 8;-Chlorobenzaldehydeoxime;ALPHA-CHLOROBENZALDOXIME;BenzohydroximoylChloride;Phenylchloromethanone oxime;Chlorophenylmethanone oxime
- CBNumber
- CB8408972
- Molecular Formula
- C7H6ClNO
- Formula Weight
- 155.58
- MOL File
- 698-16-8.mol
N-Hydroxybenzenecarboximidoyl chloride Property
- Melting point:
- 48-52°C
- Boiling point:
- 275.8±23.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.51±0.70(Predicted)
- Appearance
- White to light brown Solid
- CAS DataBase Reference
- 698-16-8(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
N-Bromosuccinimide Price
- Product number
- C651788
- Product name
- α-Chlorobenzaldoxime
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C651788
- Product name
- α-Chlorobenzaldoxime
- Packaging
- 2.5g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 101036
- Product name
- N-Hydroxybenzenecarboximidoyl chloride
- Packaging
- 5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 153224
- Product name
- N-Hydroxybenzimidoyl chloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $361
- Updated
- 2021/12/16
- Product number
- OR322225
- Product name
- alpha-chlorobenzaldoxime
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
N-Hydroxybenzenecarboximidoyl chloride Chemical Properties,Usage,Production
Chemical Properties
Colorless crystals
Synthesis
932-90-1
698-16-8
1-B. Preparation of N-hydroxybenzimidoyl chloride: refer to the method of Liu, K.C. et al. (J. Org. Chem., 45: 3916-1918, 1980). N-chlorosuccinimide (26.9 g, 201 mmol) was added to a solution of (E)-benzaldehyde oxime (24.4 g, 201 mmol) in N,N-dimethylformamide (60 mL) in batches at room temperature. After each addition, the reaction mixture first turns yellow and then gradually returns to nearly colorless. Note that the reaction is exothermic and batch addition of N-chlorosuccinimide is required to ensure smooth initiation of the reaction. If necessary, the reaction temperature can be controlled with an ice bath. After addition, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, dilute with 250 mL of water and extract with ether (3 x 100 mL). The organic layers were combined and washed sequentially with water (2 x 100 mL), 10% aqueous lithium chloride (2 x 100 mL) and brine (100 mL). The aqueous layer was then back-extracted with ether (100 mL), and all organic layers were combined (about 400 mL) and dried over anhydrous sodium sulfate. Concentration under reduced pressure afforded (Z)-N-hydroxybenzenecarbamoyl chloride (30.84 g, 198 mmol, 98% yield) as a fluffy light yellow solid. The product was analyzed by HPLC (column: CHROMOLITH? SpeedROD 4.6×50 mm; mobile phase A: 10% MeOH, 90% H2O, 0.1% TFA; mobile phase B: 90% MeOH, 10% H2O, 0.1% TFA; run time: 4 min) with a retention time of 1.57 min. LC/MS (M+1) = 155.8. 1H NMR (500 MHz, DMSO-d6) δ 7.30-7.64 (m, 3H), 7.73-7.87 (m, 2H), 12.42 (s, 1H).
References
[1] Patent: WO2010/85581, 2010, A1. Location in patent: Page/Page column 48-49
[2] Chemische Berichte, 1894, vol. 27, p. 2198
[3] Chemische Berichte, 1902, vol. 35, p. 3115
[4] Justus Liebigs Annalen der Chemie, 1927, vol. 451, p. 166
[5] Chemische Berichte, 1914, vol. 47, p. 2943
N-Hydroxybenzenecarboximidoyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Hydroxybenzenecarboximidoyl chloride manufacturers
- Product
- alpha-Chlorobenzaldoxime 698-16-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24