(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: (2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 309915-46-6
Chemical Name: (2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: (2R,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate;Felbinac Impurity 25;(2R,5S)-1-N-Boc-2,5-dimethylpiperazine;(2R,5S-TERT-BUTYL 2,5-DIMETHYLPIPERAZINE;(2R,5S)-Tert-Butyl 2,5-Dimethylpiperazine;(2R,5S)-2,5-Dimethylpiperazine, N1-Boc protected;TERT-BUTYL(2R,5S)-2,5-DIMETHYLPIPERAZINE-1-CARBOXYLATE;2,5-DiMethyl-piperazine-1-carboxylic acid tert-butyl ester;(2R,5S)-N-(tert-butyl)-2,5-dimethyl-1-piperazinecarboxamide;(2R,5S)- tert - Butyl 2,5- dimethylpiperazine -- I - carboxylate
CBNumber: CB8410616
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: Mol file

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(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 280℃
Density: 0.970
Flash point:: 123℃
storage temp.: 2-8°C(protect from light)
pka: 8.55±0.60(Predicted)
form: solid
color: Colourless to light yellow / liquid
InChI: InChI=1S/C11H22N2O2/c1-8-7-13(9(2)6-12-8)10(14)15-11(3,4)5/h8-9,12H,6-7H2,1-5H3/t8-,9+/m0/s1
InChIKey: PGZCVLUQTJRRAA-DTWKUNHWSA-N
SMILES: N1(C(OC(C)(C)C)=O)C[C@H](C)NC[C@H]1C

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB142229
Product name: (2R,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-B0967
Product name: tert-Butyl(2R,5S)-2,5-dimethylpiperazine-1-carboxylate
Purity: 99.92%
Packaging: 5g
Price: $77
Updated: 2021/12/16

Synthonix

Product number: D31865
Product name: tert-butyl(2R,5S)-2,5-dimethylpiperazine-1-carboxylate
Purity: 97+%
Packaging: 5g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142229
Product name: (2R,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate
Packaging: 1g
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-B0967
Product name: tert-Butyl(2R,5S)-2,5-dimethylpiperazine-1-carboxylate
Purity: 99.92%
Packaging: 10g
Price: $136
Updated: 2021/12/16

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(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

431062-01-0

309915-46-6

Tert-butyl 4-(4-fluorobenzyl)-(2R,5S)-dimethylpiperazine-1-carboxylate (37.8 g, 117.4 mmol) was used as a raw material and dissolved in a mixture of methanol (250 mL) and glacial acetic acid (30 mL). The mixture was transferred to a 2 L hydrogenation flask, purged with nitrogen and stirred for 10 min. Subsequently, palladium hydroxide (3.8 g, 20 wt%) was added to the mixture and the reaction was shaken at room temperature and 40 psi hydrogen pressure for 48 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and washed with methanol. The filtrate was concentrated to dryness on a rotary evaporator to afford 37.64 g (100% yield) of the target product (2R,5S)-tert-butyl (2R,5-Dimethylpiperazine-1-carboxylate), which was detected by mass spectrometry showing the M+H+ peak at 215.

References

[1] Patent: US2004/142940, 2004, A1. Location in patent: Page/Page column 29
[2] Patent: US2004/142940, 2004, A1. Location in patent: Page/Page column 44-45
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 828 - 831

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

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View Lastest Price from (2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 309915-46-6
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

309915-46-6, (2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

(2R,5R)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (2S,5R)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(2R,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

TERT-BUTYL(2R,5S)-2,5-DIMETHYLPIPERAZINE-1-CARBOXYLATE

2,5-DiMethyl-piperazine-1-carboxylic acid tert-butyl ester

(2R,5S)-N-(tert-butyl)-2,5-dimethyl-1-piperazinecarboxamide

(2R,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate

(2R,5S)-1-N-Boc-2,5-dimethylpiperazine

(2R,5S)-N-(1,1-Dimethylethyl)-2,5-dimethyl-1-piperazinecarboxamide

(2R,5S)-Tert-Butyl 2,5-Dimethylpiperazine

(2R,5S-TERT-BUTYL 2,5-DIMETHYLPIPERAZINE

(2R,5S)-2,5-Dimethylpiperazine, N1-Boc protected

1-Piperazinecarboxylic acid, 2,5-dimethyl-, 1,1-dimethylethyl ester, (2R,5S)-

(2R,5S)- tert - Butyl 2,5- dimethylpiperazine -- I - carboxylate

Felbinac Impurity 25

tert-butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate - [D31865]

309915-46-6