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(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE

Product Name
(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE
CAS No.
19036-73-8
Chemical Name
(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE
Synonyms
Einecs 242-769-7;S-Norfenfluramine;Nordexfenfluramine;Dexnorfenfluramine;(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-PROPANAMINE;(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE;(S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine;(S)-α-Methyl-3-(trifluoromethyl)benzeneethanamine;(S)-alpha-methyl-m-(trifluoromethyl)phenethylamine;[S,(+)]-α-Methyl-m-(trifluoromethyl)phenethylamine
CBNumber
CB8411178
Molecular Formula
C10H12F3N
Formula Weight
203.2
MOL File
19036-73-8.mol
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(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE Property

storage temp. 
4°C, protect from light
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0129438
Product name
(2S)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-YLAMINE
Purity
95.00%
Packaging
5MG
Price
$503.6
Updated
2021/12/16
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(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE Chemical Properties,Usage,Production

Uses

(+)-Norfenfluramine a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease[1].

Definition

ChEBI: (2S)-1-[3-(trifluoromethyl)phenyl]-2-propanamine is a member of amphetamines.

in vivo

(+)-Norfenfluramine (1-300 μg/kg, i.v.) induces pressor response in conscious SHAM and DOCA-salt rats[1].
(+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats[3].

Animal Model:Conscious SHAM and DOCA-salt rats[1].
Dosage:1-300 μg/kg
Administration:Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals.
Result:Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19).

IC 50

5-HT2B Receptor: 11.2 nM (Ki); 5-HT2A Receptor: 1516 nM (Ki); 5-HT2C Receptor: 324 nM (Ki)

References

[1] Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. DOI:10.1124/jpet.106.114017
[2] M Gobbi, et al. In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):323-7. DOI:10.1007/pl00005260
[3] R Invernizzi, et al. Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol. 1982 Mar;75(3):525-30. DOI:10.1111/j.1476-5381.1982.tb09169.x

(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE Suppliers

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19036-73-8, (S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANERelated Search:

FMOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID FMOC-L-3-Trifluoromethylphe (+)-FENFLURAMINE HYDROCHLORIDE BOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID BOC-L-3-Trifluoromethylphe (S)-ALPHA-(3-TRIFLUOROMETHYL-BENZYL)-PROLINE-HCL (R )-3-(TRIFLUOROMETHYL)PHENYLALANINE T-BUTYL ESTER (S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE (1S,2S)-(-)-N,N'-DIMETHYL-1,2-BIS[3-(TRIFLUOROMETHYL)PHENYL!-1,2-ETHANE DIAMINE, 99 BOC-(R)-ALPHA-(3-TRIFLUOROMETHYL-BENZYL)-PROLINE (R)-3-AMINO-4-(3-TRIFLUOROMETHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE BOC-(S)-ALPHA-(3-TRIFLUOROMETHYL-BENZYL)-PROLINE (R)-ALPHA-(3-TRIFLUOROMETHYL-BENZYL)-PROLINE-HCL D-3-TRIFLUOROMETHYLPHENYLALANINE (S)-2-AMINO-2-METHYL-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER (R)-2-BENZYLOXYCARBONYLAMINO-3-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID METHYL ESTER (R)-2-AMINO-3-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID RARECHEM AL CF 0912

  • (S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE
  • (S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-PROPANAMINE
  • (S)-α-Methyl-3-(trifluoromethyl)benzeneethanamine
  • [S,(+)]-α-Methyl-3-(trifluoromethyl)benzeneethanamine
  • [S,(+)]-α-Methyl-m-(trifluoromethyl)phenethylamine
  • Dexnorfenfluramine
  • Nordexfenfluramine
  • Einecs 242-769-7
  • S-Norfenfluramine
  • (S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine
  • (S)-alpha-methyl-m-(trifluoromethyl)phenethylamine
  • Benzeneethanamine, α-methyl-3-(trifluoromethyl)-, (αS)-
  • 19036-73-8
  • C10H12F3N