DIBENZOSUBERENOL

Product Name: DIBENZOSUBERENOL
CAS No.: 10354-00-4
Chemical Name: DIBENZOSUBERENOL
Synonyms: NSC 84190;DIBENZOSUBERENOL;11H-dibenzo[1,2-a;Amitriptyline Impurity 10;5H-DIBENZO[A,D][7]ANNULEN-5-OL;5H-DIBENZO [A,D]CYCLOHEPTEN-5-OL;5-Hydroxy-5H-dibenzo[a,d]cycloheptene;11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-ol
CBNumber: CB8414821
Molecular Formula: C15H12O
Formula Weight: 208.26
MOL File: 10354-00-4.mol

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DIBENZOSUBERENOL Property

Melting point:: 122.5-124 °C(lit.)
Boiling point:: 401.9±14.0 °C(Predicted)
Density: 1.196±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Solid
pka: 13.40±0.20(Predicted)
color: White to Pale Yellow
BRN: 1957458

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D31729
Product name: Dibenzosuberenol
Packaging: 10g
Price: $139.65
Updated: 2025/07/31

TRC

Product number: D417338
Product name: Dibenzosuberenol
Packaging: 500mg
Price: $185
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: DYE0000505
Product name: DIBENZOSUBERENOL
Purity: 95.00%
Packaging: 1G
Price: $635.62
Updated: 2021/12/16

Ambeed

Product number: A122825
Product name: 5H-Dibenzo[a,d][7]annulen-5-ol
Purity: 98%
Packaging: 1g
Price: $43
Updated: 2021/12/16

Ambeed

Product number: A122825
Product name: 5H-Dibenzo[a,d][7]annulen-5-ol
Purity: 98%
Packaging: 5g
Price: $125
Updated: 2021/12/16

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DIBENZOSUBERENOL Chemical Properties,Usage,Production

Uses

Dibenzosuberenol is an intermediate in the synthesis of 5H-Dibenzo[a,d]cycloheptene which itself was used in the synthesis of cyclotribenzylenes. Also functions as a calmodulin inhibitor affecting various crucial cellular processes.

Synthesis

2222-33-5

10354-00-4

General procedure for the synthesis of 5H-dibenzo[a,d]cyclohepten-5-ol from 5-dibenzo[a,d]cycloheptenone: 1.50 g (7.27 mmol) of 5-dibenzo[a,d]cycloheptenone was added to a suspension containing 4 mL of water, 0.45 mL of 1N aqueous sodium hydroxide solution and 20 mL of methanol, followed by 200 mg (5.29 mmol) of sodium borohydride. The reaction mixture was stirred overnight. Upon completion of the reaction, the precipitated crystals were collected by filtration, washed with water, and then the crystals were dissolved in ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate and the solvent was subsequently evaporated under reduced pressure to give 5H-dibenzo[a,d]cyclohepten-5-ol. Yield: 1.48 g (7.11 mmol) in 98% yield.1H-NMR (CDCl3) data: δ 2.41 (1H, d), 5.43 (1H, d), 7.11 (2H, s), 7.25-7.31 (2H, m), 7.36-7.44 (4H, m), 7.66 (2H, d).

References

[1] Patent: US2004/167118, 2004, A1. Location in patent: Page 29-30
[2] Patent: US4910312, 1990, A
[3] Patent: US4772615, 1988, A
[4] Patent: EP221572, 1991, B1
[5] Patent: EP1481673, 2004, A1. Location in patent: Page/Page column 42-43

DIBENZOSUBERENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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DIBENZOSUBERENOL Suppliers

China 62 Germany 4 India 6 Singapore 1 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 12 Global 90

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10354-00-4, DIBENZOSUBERENOLRelated Search:

DIBENZOSUBERENOL Cycloheptatriene Decitropine 10-hydroxyamitriptyline AMITRIPTYLINE-D3 HCL (N-METHYL-D3) 5-(3-DIMETHYLAMINOPROPYL)-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-OL NORTRIPTYLINE HYDROCHLORIDE Dibenzosuberone amitriptyline N-oxide Cyclobenzaprine hydrochloride AMITRIPTYLINE HCL (D6) DIBENZOSUBEROL amitriptyline N-glucuronide 10-Hydroxy Amitriptyline Oxalate Amitriptyline EP Impurity E HCl (Mixture of Diastereomers) AMitriptyline-N-Glucuronide-d3 5-Hydroxy-5-methyl-5H-dibenzo[a,d]cycloheptene 5-(2-BROMOETHOXY)-3-CHLORO-5H-DIBENZO[A,D]CYCLOHEPTENE

5H-DIBENZO [A,D]CYCLOHEPTEN-5-OL

DIBENZOSUBERENOL

5-Hydroxy-5H-dibenzo[a,d]cycloheptene

5H-DIBENZO[A,D][7]ANNULEN-5-OL

11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-ol

NSC 84190

Amitriptyline Impurity 10

11H-dibenzo[1,2-a

10354-00-4

ALCOHOL

Organic Building Blocks

Oxygen Compounds

Phenols

Building Blocks