DEHYDROXYMETHYLEPOXYQUINOMICIN

Product Name: DEHYDROXYMETHYLEPOXYQUINOMICIN
CAS No.: 287194-40-5
Chemical Name: DEHYDROXYMETHYLEPOXYQUINOMICIN
Synonyms: DHMEQ;DHM2EQ;()DHMEQ,( ) DHMEQ;DEHYDROXYMETHYLEPOXYQUINOMICIN;Dehydroxymethylepoxyquinomicin (DHMEQ);(-)-DHMEQ?(dehydroxymethylepoxyquinomicin);2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzaMide;Benzamide, 2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-;2-hydroxy-N-[(1aS,2S,5aS)-2-hydroxy-5-oxo-1a,2,5,5a-tetrahydrocyclohexa[1,2-b]oxiren-3-yl]benzamide
CBNumber: CB8419477
Molecular Formula: C13H11NO5
Formula Weight: 261.23
MOL File: 287194-40-5.mol

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DEHYDROXYMETHYLEPOXYQUINOMICIN Property

Melting point:: 187 °C
Boiling point:: 617.2±55.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 32 mg/mL (122.50 mM)
pka: 8.43±0.30(Predicted)
form: Solid
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5488
Product name: (-)-DHMEQ
Purity: 98.83%
Packaging: 2mg
Price: $168
Updated: 2021/12/16

ChemScene

Product number: CS-5488
Product name: (-)-DHMEQ
Purity: 98.83%
Packaging: 5mg
Price: $264
Updated: 2021/12/16

ChemScene

Product number: CS-5488
Product name: (-)-DHMEQ
Purity: 98.83%
Packaging: 10mg
Price: $360
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001467
Product name: DHMEQ
Purity: 95.00%
Packaging: 5MG
Price: $496.86
Updated: 2021/12/16

ChemScene

Product number: CS-5488
Product name: (-)-DHMEQ
Purity: 98.83%
Packaging: 25mg
Price: $720
Updated: 2021/12/16

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DEHYDROXYMETHYLEPOXYQUINOMICIN Chemical Properties,Usage,Production

Uses

(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity[1][2][3].

in vivo

(-)-DHMEQ (4 mg/kg or 12 mg/kg; intraperitoneal injection; on day 0 and 3 times a week; for one month; SCID mice) treatment shows a significant increase in the survival rate in mice^[2].

Animal Model:	Male C.B17-scid/scid (5 weeks old) mice injected with MT-2 cells^[2]
Dosage:	4 mg/kg or 12 mg/kg
Administration:	Intraperitoneal injection; on day 0 and 3 times a week; for one month
Result:	Showed a significant increase in the survival rate in mice.

IC 50

RelA; RelB

References

[1] Yinzhi Lin, et al. Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review. DOI:10.3390/ijms19030729
[2] Mariko Watanabe, et al. Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia. Blood. 2005 Oct 1;106(7):2462-71. DOI:10.1182/blood-2004-09-3646
[3] Quach HT, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor κB Subunit RelB in Response to a Lymphotoxin β Stimulation. Biol Pharm Bull. 2017;40(10):1669-1677. DOI:10.1248/bpb.b17-00170

DEHYDROXYMETHYLEPOXYQUINOMICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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DEHYDROXYMETHYLEPOXYQUINOMICIN Suppliers

China 25 United States 6 Global 31

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287194-40-5, DEHYDROXYMETHYLEPOXYQUINOMICINRelated Search:

2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzaMide

Dehydroxymethylepoxyquinomicin (DHMEQ)

DEHYDROXYMETHYLEPOXYQUINOMICIN

DHM2EQ

DHMEQ

Benzamide, 2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-

(-)-DHMEQ?(dehydroxymethylepoxyquinomicin)

()DHMEQ,( ) DHMEQ

2-hydroxy-N-[(1aS,2S,5aS)-2-hydroxy-5-oxo-1a,2,5,5a-tetrahydrocyclohexa[1,2-b]oxiren-3-yl]benzamide

287194-40-5