HS-1793
- Product Name
- HS-1793
- CAS No.
- 927885-00-5
- Chemical Name
- HS-1793
- Synonyms
- HS-1793;HS-1793, 10 mM in DMSO;1,3-Benzenediol, 4-(6-hydroxy-2-naphthalenyl)-;HIF-1α,Inhibitor,MCF-7,HS 1793,breast cancer,inhibit,ERK,HCT116,resveratrol,VEGF,Apoptosis,HS-1793,Akt,colon cancer,HS1793
- CBNumber
- CB84198169
- Molecular Formula
- C16H12O3
- Formula Weight
- 252.26
- MOL File
- 927885-00-5.mol
HS-1793 Property
- Melting point:
- 186 °C
- Boiling point:
- 520.8±19.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- pka
- 9.31±0.35(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- InChI
- InChI=1S/C16H12O3/c17-13-4-3-10-7-12(2-1-11(10)8-13)15-6-5-14(18)9-16(15)19/h1-9,17-19H
- InChIKey
- BXZJBSHLEZAMOP-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(C2=CC=C3C(=C2)C=CC(O)=C3)C(O)=C1
N-Bromosuccinimide Price
- Product number
- SYN5465
- Product name
- HS-1793
- Packaging
- 10mg
- Price
- $273
- Updated
- 2021/12/16
- Product number
- SYN5465
- Product name
- HS-1793
- Packaging
- 50mg
- Price
- $968
- Updated
- 2021/12/16
HS-1793 Chemical Properties,Usage,Production
Uses
HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines[1]. HS-1793 induces cell apoptosis[2].
in vivo
HS-1793 (5 and 10 mg/kg; i.p.; twice a week, 4 weeks) significantly inhibits MDA-MB-231 xenograft tumor growth and in a dose-dependent manner and relatively hampers angiogenesis with non-toxicity[1].
| Animal Model: | Five-week-old female BALB/c nude mice injected with MDA-MB-231 cells[1] |
| Dosage: | 5 mg/kg and 10 mg/kg (dissolved in PBS containing 0.1% v/v dimethyl sulfoxide (DMSO)) |
| Administration: | Intraperitoneal injection, twice a week, 4 weeks |
| Result: | Significantly inhibited MDA-MB-231 xenograft tumor growth in a dose-dependent manner with non-toxicity. Significantly lowered Ki-67 (a proliferation marker) and CD31 expression. Successfully suppressed the expression of HIF-1α and VEGF in tumor tissues. |
References
[1] Kim DH, et al. HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model. Int J Oncol. 2017 Aug;51(2):715-723. DOI:10.3892/ijo.2017.4058
[2] Kim DH, et al. Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncol Rep. 2017 Jan;37(1):281-288. DOI:10.3892/or.2016.5219
HS-1793 Preparation Products And Raw materials
Raw materials
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