2,1,3-BENZOTHIADIAZOLE-5-CARBONYL CHLORIDE Property

Melting point:

111 °C

Boiling point:

297.6±13.0 °C(Predicted)

Density 

1.577±0.06 g/cm3(Predicted)

pka

-1.13±0.36(Predicted)

CAS DataBase Reference

321309-31-3(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

34

Safety Statements 

26-36/37/39

RIDADR 

3261

Hazard Note 

Irritant

HS Code 

2934999090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

2,1,3-BENZOTHIADIAZOLE-5-CARBONYL CHLORIDE Chemical Properties,Usage,Production

Uses

2,1,3-Benzothiadiazole-5-carbonyl chloride is used as a reactant in the preparation of phthalazinones as PARP inhibitors for use in the treatment of cancer which is deficient in HR dependent DNA DSB repair pathway.