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CX-1632

Product Name
CX-1632
CAS No.
1038984-31-4
Chemical Name
CX-1632
Synonyms
S47445;S-47445;CX-1632;S 47445;Tulrampator (CX-1632);Tulrampator 1038984-31-4;Tulrampator, 10 mM in DMSO;Tulrampator (Synonyms: CX-1632);TULRAMPATOR; S-47445; S 47445; S47445; CX-1632; CX 1632; CX1632;;iGluR,Ionotropic glutamate receptors,Inhibitor,CX 1632,Tulrampator,inhibit,CX1632
CBNumber
CB84204158
Molecular Formula
C20H17FN4O3
Formula Weight
380.37
MOL File
1038984-31-4.mol
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CX-1632 Property

storage temp. 
Store at -20°C
solubility 
DMSO:21.67(Max Conc. mg/mL);56.97(Max Conc. mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0031490
Product name
Tulrampator
Purity
99.40%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0031490
Product name
Tulrampator
Purity
99.40%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0031490
Product name
Tulrampator
Purity
99.40%
Packaging
50mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0031490
Product name
Tulrampator
Purity
99.40%
Packaging
100mg
Price
$750
Updated
2021/12/16
DC Chemicals
Product number
DC20133
Product name
Tulrampator(CX-1632)
Purity
>98%
Packaging
100mg
Price
$450
Updated
2021/12/16
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CX-1632 Chemical Properties,Usage,Production

Uses

Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder[1][2][3].

in vivo

Tulrampator (0.3-10 mg/kg, Oral gavage, once a day for 4-5 weeks) has anxiolytic-like and antidepressant-like effects in the CORT Mice Model[2].
Tulrampator (1-10 mg/kg, Intraperitoneal injection, once a day for 4 weeks) reverts olfactory bulbectomy (OB)-induced hyperactivity and anxiety in bilateral olfactory bulbectomy mice model[3].

Animal Model:chronic corticosterone administration (CORT) mice[2]
Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Oral gavage (p.o.)
Result:Reversed anxio-depressive phenotype in a neurogenesis-dependent task.
Decreased the corticosterone-induced increase in emotionality.
Had a rapid onset of effect on anhedonia in the rat Chronic Mild Stress (CMS) model.
Stimulated cell proliferation, survival and neuronal maturation in the dentate gyrusof the hippocampus.
Animal Model:bilateral olfactory bulbectomy mice model[3]
Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Significantly reverted OB-induced hyperactivity after 28 days.
Increased open field central activity in OB mice.

References

[1] Bretin S, et al. Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors [J]. PLoS One, 2017, 12(9): e0184429.
[2] Mendez-David I, et al. S 47445 produces antidepressant-and anxiolytic-like effects through neurogenesis dependent and independent mechanisms [J]. Frontiers in pharmacology, 2017, 8: 462.
[3] Pilar-Cuellar F, et al. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice [J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019, 93: 205-213.
[4] Wilkinson ST, et al. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today. 2018 Nov 14. pii: S1359-6446(18)30376-3. DOI:10.1016/j.drudis.2018.11.007

CX-1632 Preparation Products And Raw materials

Raw materials

Preparation Products

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CX-1632 Suppliers

China 29 United States 1 Global 30
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
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64
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
Shanghai Yinlin Pharmaceutical Co., Ltd.
Tel
021-33690831
Fax
021-33690831
Email
813300142@qq.com
Country
China
ProdList
305
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58

1038984-31-4, CX-1632Related Search:


  • CX-1632
  • Tulrampator 1038984-31-4
  • Tulrampator (Synonyms: CX-1632)
  • Tulrampator (CX-1632)
  • S 47445
  • S47445
  • S-47445
  • TULRAMPATOR; S-47445; S 47445; S47445; CX-1632; CX 1632; CX1632;
  • 3H-[1,3]Oxazino[6,5-g]-1,2,3-benzotriazine-4,9-dione, 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-
  • iGluR,Ionotropic glutamate receptors,Inhibitor,CX 1632,Tulrampator,inhibit,CX1632
  • 13-cyclopropyl-6-[2-(3-fluorophenyl)ethyl]-11-oxa-4,5,6,13-tetraazatricyclo[8.4.0.03,?]tetradeca-1(10),2,4,8-tetraene-7,14-dione
  • 8-cyclopropyl-3-(3-fluorophenethyl)-7,8-dihydro-3H-[1,3]oxazino[6',5':4,5]benzo[1,2-d][1,2,3]triazine-4,9-dione
  • Tulrampator, 10 mM in DMSO
  • 1038984-31-4