P-CHLOROBENZOIC ANHYDRIDE
- Product Name
- P-CHLOROBENZOIC ANHYDRIDE
- CAS No.
- 790-41-0
- Chemical Name
- P-CHLOROBENZOIC ANHYDRIDE
- Synonyms
- AI314648;AI3-14648;AI3 14648;4-CHLOROBENZOIC ANHYDRIDE;P-CHLOROBENZOIC ANHYDRIDE;bis(4-chlorobenzoic) anhydride;(4-chlorobenzoyl) 4-chlorobenzoate;4-chloro-Benzoic acid 1,1'-anhydride;Benzoic acid, 4-chloro-, 1,1'-anhydride;(4-chlorophenyl)carbonyl 4-chlorobenzoate
- CBNumber
- CB8423867
- Molecular Formula
- C14H8Cl2O3
- Formula Weight
- 295.12
- MOL File
- 790-41-0.mol
P-CHLOROBENZOIC ANHYDRIDE Property
- Melting point:
- 193-194 °C(Solv: water (7732-18-5); acetone (67-64-1))
- Boiling point:
- 248 °C(Press: 5 Torr)
- Density
- 1.401±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Acetone (Slightly), Chloroform (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Moisture Sensitive
Safety
- Hazard Codes
- T
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C427630
- Product name
- 4-Chlorobenzoicanhydride
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 2359AC
- Product name
- 4-Chlorobenzoicanhydride
- Packaging
- 5g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- HCH0028379
- Product name
- PARA-CHLORO BENZOIC ANHYDRIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- A412141
- Product name
- 4-Chlorobenzoicanhydride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- A412141
- Product name
- 4-Chlorobenzoicanhydride
- Purity
- 97%
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
P-CHLOROBENZOIC ANHYDRIDE Chemical Properties,Usage,Production
Preparation
To a flask containing 17.5 gm (0.1 mole) of p-chlorobenzoyl chloride is added 50 ml (0.6 mole) of pyridine and the mixture heated for 5 min on the steam bath. The mixture is poured upon 100 gm of cracked ice and 50 ml of concentrated hydrochloric acid, allowed to warm to room temperature, filtered, the solid washed successively with 15 ml of methanol and 15 ml of dry benzene, and dried to afford 14.2-14.6 gm (96-98%), m.p. 192- 193°C (recrystallized from 250 ml of dry benzene).
Synthesis
74-11-3
790-41-0
GENERAL METHOD: Iodine (0.1573 g, 0.62 mmol) was dissolved in dichloromethane (2 mL) at 0 °C, followed by a one-time addition of triphenylphosphine (0.1626 g, 0.62 mmol). Next, p-chlorobenzoic acid (0.41 mmol) was added to the mixture, and triethylamine (0.17 mL, 1.23 mmol) was added at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously until the reaction was complete (usually about 10 minutes). Upon completion of the reaction, the crude product was concentrated under reduced pressure and subsequently purified by column chromatography (CC) using a hexane solution of 5-10% ethyl acetate as eluent to give the final 4-chlorobenzoic anhydride.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 3, p. 325 - 328
[2] Synthesis, 1981, # 8, p. 616 - 620
[3] Tetrahedron Letters, 1986, vol. 27, # 41, p. 4937 - 4940
[4] Synthesis, 1981, # 3, p. 218 - 220
[5] Synthetic Communications, 1983, vol. 13, # 6, p. 471 - 488
P-CHLOROBENZOIC ANHYDRIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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