(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
- Product Name
- (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
- CAS No.
- 745055-91-8
- Chemical Name
- (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
- Synonyms
- UBP 302;UBP302, PUBCHEM CID: 6420161;(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE;2-[[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid;(αS)-α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid;1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-, (αS)-
- CBNumber
- CB8428312
- Molecular Formula
- C15H15N3O6
- Formula Weight
- 333.3
- MOL File
- Mol file
(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Property
- Melting point:
- 207.9-208.5 °C (decomp)(Solv: water (7732-18-5))
- Boiling point:
- 603.0±65.0 °C(Predicted)
- Density
- 1.525±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: ≥5mg/mL at 60°C (with warming for 5 minutes)
- pka
- 2.12±0.10(Predicted)
- form
- powder
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- U4135
- Product name
- UBP302
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $198
- Updated
- 2022/05/15
- Product number
- 24309
- Product name
- UBP 302
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 24309
- Product name
- UBP 302
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 2079
- Product name
- UBP302
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $292
- Updated
- 2021/12/16
- Product number
- U103505
- Product name
- UBP302
- Packaging
- 2.5mg
- Price
- $370
- Updated
- 2021/12/16
(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Chemical Properties,Usage,Production
Description
UBP 302 is an antagonist of glutamate receptor 5 (GluR5) subunit-containing kainate receptors that inhibits kainate-induced responses in isolated rat dorsal roots (Kd = 402 nM). In vitro, UBP 302 inhibits gamma frequency oscillations in the rat basolateral amygdala at a concentration of 25 μM, and blocks kainate receptor signaling in layer III neurons within the mouse medial entorhinal cortex at 20 μM, abrogating the intense synaptic activity characteristic of the Up state of cortical slow oscillation. In vivo, UBP 302 (250 mg/kg) significantly reduces seizure severity in a rat model of soman-induced status epilepticus.
Uses
UBP 302 is a potent and selective GLUK5 receptor antagonist.
Biological Activity
Selective and potent GLU K5 (GluR5)-subunit containing kainate receptor antagonist (apparent K D = 402 nM); active enantiomer of UBP 296 ((RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione ). Displays ~ 260-fold selectivity over AMPA receptors. UBP 296 displays ~ 90-fold selectivity over recombinant human GLU K6 - and GLU K2 -containing kainate receptors, has little or no action at NMDA or group I mGlu receptors and selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres.
storage
Room temperature
(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77