ALDOSTERONE
- Product Name
- ALDOSTERONE
- CAS No.
- 52-39-1
- Chemical Name
- ALDOSTERONE
- Synonyms
- Reichstein;REICHSTEIN X;LECTROCORTIN;μ100 97% (CP);ALD ELISA;NSC 73856;Aldocorten;Aldocortin
- CBNumber
- CB8431679
- Molecular Formula
- C21H28O5
- Formula Weight
- 360.45
- MOL File
- 52-39-1.mol
ALDOSTERONE Property
- Melting point:
- 170-172°C
- alpha
- D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform)
- Boiling point:
- 412.46°C (rough estimate)
- Density
- 1.28
- refractive index
- 1.6120 (estimate)
- Flash point:
- 2℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 12.98±0.10(Predicted)
- color
- White
- Water Solubility
- 51.18mg/L(37 ºC)
- Merck
- 13,224
- BRN
- 3224996
- CAS DataBase Reference
- 52-39-1(CAS DataBase Reference)
- EPA Substance Registry System
- Aldosterone (52-39-1)
Safety
- Hazard Codes
- Xi,Xn,F
- Risk Statements
- 36/37/38-36-20/21/22-11
- Safety Statements
- 22-24/25-36-26-36/37-16
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 3
- RTECS
- TU4523000
- F
- 22-24-25
- HS Code
- 29372900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A9477
- Product name
- Aldosterone
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- A-096
- Product name
- Aldosterone solution
- Purity
- 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $231
- Updated
- 2024/03/01
- Product number
- 15273
- Product name
- Aldosterone
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15273
- Product name
- Aldosterone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- A9477
- Product name
- Aldosterone
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $375
- Updated
- 2024/03/01
ALDOSTERONE Chemical Properties,Usage,Production
Description
Aldosterone is a mineralocorticosteroid that takes part in the regulation of electrolytic balance in the organism. Aldosterone lowers excretion of sodium ions from the body, thus increasing their reabsorption and increasing secretion of potassium ions in renal tubules. Being a competitive antagonist of aldosterone, spironlactone blocks aldosterone receptors, thus increasing excretion of sodium, chloride, and corresponding equivalents of water with urine, thus retaining the amount of potassium ions in the organism. Spironolactone is used both individually as well as in combination with thiazides, since it lowers kaliuresis caused by thiazide diuretics.
Chemical Properties
White Solid
Originator
Aldosterone ,Sigma Chemical Company
Uses
A labelled adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex that induces urinary excretion of K+ and renal re
Uses
The d-isomer of aldosterone is considered to be the biologically active isomer.
Uses
Labelled Aldosterone. Aldosterone is an adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Biologically active aldosterone isomer; a mineralocorticoid pr oduced by the adrenal cortex that induces urinary excretion of K+ and renal reabsorptioon of Na+. Exists as an equilibrium mixture of the aldehyde and the hemiacetal.
Uses
Imatinib intermediate
Uses
hypnotic, anastethic
Definition
ChEBI: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, i creased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Definition
aldosterone: A hormone producedby the adrenal glands that controlsexcretion of sodium by the kidneysand thereby maintains the balance ofsalt and water in the body fluids.
Therapeutic Function
Mineralocorticoid
Biological Functions
Aldosterone, produced by the adrenal cortex, acts at epithelial
cells in the distal tubule of the nephron to increase
the reabsorption of sodium and is therefore considered an important hormone in the regulation of electrolyte
balance. Aldosterone exerts its effects at the
nephron through mineralocorticoid receptors, which
translocate to the nucleus upon aldosterone binding
and exert genomic effects leading to increased sodium
reabsorption. In addition to the epithelial effects of aldosterone
at mineralocorticoid receptors, nonepithelial
cells, including cardiac muscle and vascular smooth
muscle cells and cells in the brain, can respond to aldosterone
and result in left ventricular hypertrophy,
cardiac and vascular fibrosis, and stimulation of sympathetic
nervous system activity.
Spironolactone (Aldactone), an antagonist of the aldosterone
mineralocorticoid receptor, is used to treat primary
aldosteronism, essential hypertension, and congestive
heart failure. In the treatment of
hypertension resulting from adrenal adenoma (primary aldosteronism)
and in patients with essential hypertension,
spironolactone lowers blood pressure primarily through
blockade of epithelial mineralocorticoid receptors in the
kidney, reductions in sodium and water reabsorption, and
diuresis.The use of spironolactone in the treatment of essential
hypertension is typically restricted to patients who
do not respond appropriately to other agents and is often
used in combination drug therapy. In large-scale clinical
trials in patients with severe heart failure, administration
of spironolactone markedly reduced morbidity and mortality
without reducing blood pressure. Spironolactone is
used to treat patients with moderate to severe heart failure
who exhibit symptoms and ventricular dysfunction despite
treatment with an ACE inhibitor or a diuretic.
Adverse effects of spironolactone therapy include
hyperkalemia, gastrointestinal problems, gynecomastia
(breast enlargement in males), and impotence. Gynecomastia
and impotence arising from spironolactone
treatment are results of significant blockade of the androgen
and mineralocorticoid receptors.Novel selective
mineralocorticoid receptor antagonists, such as eplerenone,
are in clinical trials.
Health Hazard
Aldosterone(Aldocortin; electrocortin; mineralocorticoid; 18-oxocorticosterone): (1)Maintenance of normal electrolyte blood balances;(2)Prolongs survival of adrenalectomized animals;(3)Accelerates gluconeogenesis;(4)Regulates kidney function.
Synthesis
Aldosterone, 11|?,21-dihydroxypregn-4-en-2,18,20-trione (27.2.4), is synthesized from 21-O-acetylcorticosterone, which when reacted with nitrosyl chloride in pyridine gives the nitrite 27.2.1. When photochemically irradiated, this compound is transformed to the oxime 27.2.2, which is hydrolyzed by nitrous acid and forms the semiacetal 27.2.3, which is an acetate of the desired aldosterone. Alkaline hydrolysis of the acetyl group of this compound leads to the desired aldosterone (27.2.4) .
Purification Methods
Crystallise aldosterone from aqueous acetone. It exists in solution as an equilibrium mixture of free aldehyde and its cyclic hemiacetal, favouring the hemiacetal. The 21-acetate crystallises from Me2CO/Et2O or CH2Cl2/EtOAc and has m 198-199o, [] D +121.7o (c 0.7, CHCl3). [Barton et al. J Chem Soc Perkin Trans 1 2243 1975, Beilstein 8 IV 3491.]
ALDOSTERONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ALDOSTERONE manufacturers
- Product
- ALDOSTERONE 52-39-1
- Price
- US $110.00-90.00/kilogram
- Min. Order
- 1kilogram
- Purity
- 99%
- Supply Ability
- 10 tons/per week
- Release date
- 2024-02-27
- Product
- ALDOSTERONE 52-39-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24