(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID

Product Name: (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID
CAS No.: 261165-05-3
Chemical Name: (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID
Synonyms: BOC-(1S,3R)-3-Aminocyclopentanecarboxylic acid;(+)-(1S,3R)-N-Boc-b-homocycloleucine;(+)-(1S,3R)-N-Boc-β-Homocycloleucine;(+)-(1S,3R)-N-BOC-BETA-HOMOCYCLOLEUCINE;(1S,3R)-Boc-3-aminocyclopentane-1carboxylicaci;(1S,3R)-Boc-3-aminocyclopentane-1 carboxylic acid;(1R,3S)-N-BOC-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID;(1S,3R)-3-[N-BOC-Amino]cyclopentane-carboxylic acid;(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID;(1S,3R)-(+)-3-(BOC-AMINO)CYCLOPENTANECARBOXYLIC ACID
CBNumber: CB8441571
Molecular Formula: C11H19NO4
Formula Weight: 229.27
MOL File: 261165-05-3.mol

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(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID Property

Melting point:: 35-49 °C
Boiling point:: 371.18°C (rough estimate)
Density: 1.1482 (rough estimate)
refractive index: 1.4490 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: slightly sol. in Methanol
pka: 4.62±0.40(Predicted)
form: Powder or Chunks
color: White
optical activity: [α]/D +16.0±1°, c = 1% in methanol
InChI: InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-8-5-4-7(6-8)9(13)14/h7-8H,4-6H2,1-3H3,(H,12,15)(H,13,14)/t7-,8+/m0/s1
InChIKey: RNJQBGXOSAQQDG-JGVFFNPUSA-N
SMILES: [C@H]1(C(O)=O)CC[C@@H](NC(OC(C)(C)C)=O)C1

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29223900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4397
Product name: (1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid
Purity: >95.0%(GC)(T)
Packaging: 200mg
Price: $105
Updated: 2024/03/01

Cayman Chemical

Product number: 11406
Product name: BOC-(1S,3R)-3-Aminocyclopentanecarboxylic acid
Purity: ≥95%
Packaging: 50mg
Price: $85
Updated: 2024/03/01

TRC

Product number: B617665
Product name: (-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylicAcid
Packaging: 50mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56208
Product name: (1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylic acid
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Chem-Impex

Product number: 15260
Product name: (+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylicacid,97%(HPLC)
Purity: 97%(HPLC)
Packaging: 100MG
Price: $67.2
Updated: 2021/12/16

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(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

white powder or chunks

Uses

(-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylic Acid is a reagent used in the synthesis of 3-substituted aminocyclopentanes as potent NR2B subtype-sellective NMDA antagonists in the treatment of neuropathic pain and Parkinson’s.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

151907-80-1

261165-05-3

The general procedure for the synthesis of (1S,3R)-3-((tert-butoxycarbonyl)amino)cyclopent-2-enecarboxylic acid using (1R,4S)-4-((tert-butoxycarbonyl)amino)cyclopent-2-enecarboxylic acid as a starting material was as follows: (1R,4S)-4-((tert-butoxycarbonyl)amino)cyclopent-2-enecarboxylic acid (230 g, 1.0 mol) prepared in step A was hydrogenated with 10% Pd/ C catalyst (5.0 g) in 500 mL of methanol and hydrogenated on a Parr shaker at 50 psi hydrogen pressure for 1 hour. Upon completion of the reaction, the catalyst was removed by filtration followed by evaporation of the filtrate to remove the solvent. The resulting residue was dissolved in dichloromethane and dried by adding anhydrous sodium sulfate. After filtration again, the filtrate was evaporated and dried under vacuum to afford (1S,3R)-3-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid as a light yellow solid (230 g, 99% yield). Analyzed by LC-MS, the calculated value of [M+H+] for C11H19NO4 was 230 and the measured value was 230, which was as expected.

References

[1] Patent: WO2004/76411, 2004, A2. Location in patent: Page 28
[2] Patent: WO2003/93231, 2003, A2. Location in patent: Page/Page column 56
[3] Patent: US2007/155731, 2007, A1. Location in patent: Page/Page column 27; 36
[4] Patent: WO2005/110409, 2005, A2. Location in patent: Page/Page column 30
[5] Patent: WO2005/75426, 2005, A1. Location in patent: Page/Page column 28

(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID Suppliers

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View Lastest Price from (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID 261165-05-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 500kg/month
Release date: 2019-08-01

261165-05-3, (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACIDRelated Search:

BOC-1,3-CIS-ACHC-OH (-)-(1S,4R)-N-BOC-4-AMINOCYCLOPENT-2-ENECARBOXYLIC ACID 3-AMINOCYCLOPENTANECARBOXYLIC ACID BOC-1-AMINOCYCLOPENTANECARBOXYLIC ACID (1R,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID 95% (98% E.E.) BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID (1R,2S,4S)-N-BOC-1-AMINO-2-HYDROXYCYCLOPENTANE-4-CARBOXYLIC ACID METHYL ESTER (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID (-)-(1R,3S)-N-Boc-3-Aminocyclopentanecarboxylic acid 4-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[2.1.1]HEXANE-1-CARBOXYLIC ACID (1R,2R,4S)-N-BOC-1-AMINO-2-HYDROXYCYCLO-PENTANE-4-CARBOXYLIC ACID METHYL ESTER C(1S,2S,3R,4R)-3-(1-ACETYLAMINO-2-ETHYLBUYL)-4-TUBOXYCARBONYL-AMINO-2-METHYLCYCLOPENTANE CARBOXYLIC ACID METHYL ESTER

Cyclopentanecarboxylicacid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, (1S,3R)-

(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID

(+)-(1S,3R)-N-BOC-BETA-HOMOCYCLOLEUCINE

(1S,3R)-(+)-3-(BOC-AMINO)CYCLOPENTANECARBOXYLIC ACID

(1R,3S)-N-TERT-BUTOXYCARBONYL-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID

(-)-(1R,3S)-N-ALPHA-T-BUTOXYCARBONYL-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID

(+)-(1R,3S)-N-BOC-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID

(1R,3S)-N-BOC-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID

(1R,3S)-N-boc-1-Aminocyclopentane-3-carboxylicacid(e.e.)

(1S,3R)-(+)-3-Aminocyclopentanecarboxylic acid, N-BOC protected

Cis-3-(N-Tert-Butoxycarbonylamino)Cyclopentanecarboxylic Acid

(+)-(1S,3R)-N-Boc-b-homocycloleucine

(1R,3s)-N-Boc-1-aminocyclopentane-3-carboxylic acid, 95%, ee:98%

(1R,3S)-N-BOC-1-Aminocyclopentane-3-carboxylic acid, 98% ee

(1R,3S)-N-BOC-1-Aminocyclopentane-3-carboxylic acid,95%,98% ee

(1R,3S)-N-BOC-1-Aminocyclopentane-3-carboxylic acid(1R,3S)-N-tert-Butoxycarbonyl-1-aminocyclopentane-3-carboxylic acid

(1S,3R)-Boc-3-aminocyclopentane-1 carboxylic acid

(1S,3R)-(+)-3-[(tert-Butoxycarbonyl)amino]cyclopentane-1-carboxylic acid

(1S,3R)-(+)-3-Aminocyclopentane-1-carboxylic acid, N-BOC protected

(+)-(1S,3R)-N-Boc-3-aMinocyclopentanecarboxylic acidacid

(1S,3R)-3-((tert-Butoxycarbonyl)aMino)cyclopentanecarboxylic acid

Cis(1S,3R)-3-((tert-butoxycarbonyl)aMino) cyclopentanecarboxylic acid

(1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylic acid >=96.0% (HPLC)

(+)-(1S,3R)-N-(Tert-Butoxy)Carbonyl 3-Aminocyclopentanecarboxylic acid

BOC-(1S,3R)-3-Aminocyclopentanecarboxylic acid

(1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid

(1S,3R)-(+)-3-Aminocyclopentane-1-carboxylic acid, N-BOC protected 97%

(1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid &gt

(1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylicacid,95%

(1S,3R)-Boc-3-aminocyclopentane-1carboxylicaci

(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID USP/EP/BP

(+)-(1S,3R)-3-[(t-Butoxycarbonyl)amino]cyclopentanecarboxylic acid

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylicacidacid

(-)-(1R,3s)-n-boc-1-aminocyclopentane-3-carboxylic acid

(+)-(1S,3R)-N-Boc-β-Homocycloleucine

(1S,3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclopentanecarboxylic acid

(+)-(1S,3R)-N-Fmoc3-aminocyclopentanecarboxylicacidacid

(1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylic acid

(+)-(1S,3R)-N-Boc-3-Aminocyclopentanecarboxylic acid

(1S,3R)-3-[N-BOC-Amino]cyclopentane-carboxylic acid

261165-05-3

Beta-Amino Acids

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Unusual amino acids

API intermediates

Beta-Amino Acids

Peptide Synthesis