BUTTPARK 148\07-01
Uses- Product Name
- BUTTPARK 148\07-01
- CAS No.
- 20780-75-0
- Chemical Name
- BUTTPARK 148\07-01
- Synonyms
- 4-Iodoisatin;BUTTPARK 148\07-01;4-iodoindoline-2,3-dione;4-IODO-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 4-iodo-;4-iodoindoline-2,3-dione,4-IODOISATIN;4-iodo-2,3-dihydro-1H-indole-2,3-dione;4-iodo-2,3-dihydro-1H-indole-2,3-dione - [K84624]
- CBNumber
- CB8452379
- Molecular Formula
- C8H4INO2
- Formula Weight
- 273.03
- MOL File
- 20780-75-0.mol
BUTTPARK 148\07-01 Property
- Melting point:
- 227-229°
- Density
- 2.106±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.88±0.20(Predicted)
- Appearance
- Brown to orange Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I706445
- Product name
- 4-Iodoindoline-2,3-dione
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- I706445
- Product name
- 4-Iodoindoline-2,3-dione
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR471590
- Product name
- 4-Iodoindoline-2,3-dione
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 4H48-H-25
- Product name
- 4-Iodoindoline-2,3-dione
- Packaging
- 1g
- Price
- $96
- Updated
- 2021/12/16
- Product number
- 045906
- Product name
- 4-Iodo-1H-indole-2,3-dione
- Purity
- >95%
- Packaging
- 500mg
- Price
- $244
- Updated
- 2021/12/16
BUTTPARK 148\07-01 Chemical Properties,Usage,Production
Uses
4-Iodine indigo is a heterocyclic organic compound that can be used as a pharmaceutical synthesis intermediate.
Synthesis
63608-68-4
20780-75-0
General procedure for the synthesis of 4-iodoindoline-2,3-dione from 2-(N-hydroxyimino)-N-(3-iodophenyl)acetamide: Sulfuric acid (1L) was placed in a 3L beaker on a hot plate, heated to 60°C and removed from the heat source. Compound 8a was added in batches over a period of 30 minutes under continuous stirring, controlling the reaction temperature to not exceed 65 °C. Subsequently, the reaction mixture was heated to 80 °C and maintained for 15 min, after which it was cooled to 70 °C and placed in an ice bath for further cooling. The reaction solution was slowly decanted into crushed ice (5 L) and allowed to stand for 1 h. The orange-red precipitate was collected by filtration. The product was washed with deionized water (400 mL) with stirring and filtered again to give a mixture of compound 8b with 6-iododihydroindole-2,3-dione. The crude product was dissolved in a solution of deionized water (200 mL) containing sodium hydroxide (20 g) and heated to 60 °C to dissolve it completely, followed by adjusting the pH with acetic acid to 4.9. After standing for 0.5 h and cooling to 35 °C, the precipitate of compound 8b precipitated was filtered and washed with deionized water (50 mL) to give the final product (38.37 g, 59% yield). Mass spectrometry analysis showed [M+H]+ m/z 274.
References
[1] Patent: WO2017/211303, 2017, A1. Location in patent: Page/Page column 40
[2] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 370 - 378
BUTTPARK 148\07-01 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BUTTPARK 148\07-01 manufacturers
- Product
- 4-iodoindoline-2,3-dione 20780-75-0
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-12