AKOS B006681
- Product Name
- AKOS B006681
- CAS No.
- 1204-32-6
- Chemical Name
- AKOS B006681
- Synonyms
- AKOS B006681;ART-CHEM-BB B006681;RARECHEM AL BF 0557;Methyl 1-Methylindole-6-carboxylate;6-(Methoxycarbonyl)-1-methyl-1H-indole;Methyl 1-Methyl-1H-indole-6-carboxylate;N-Methylindole-3-carboxylicacidmethylester;1-Methyl-1H-indole-6-carboxylic acid Methyl ester;1H-Indole-6-carboxylic acid, 1-methyl-, methyl ester;1-methyl-1H-Indole-6-carboxylic acid methyl ester (9CI ACI)
- CBNumber
- CB8452410
- Molecular Formula
- C11H11NO2
- Formula Weight
- 189.21
- MOL File
- 1204-32-6.mol
AKOS B006681 Property
- Melting point:
- 90～93℃
- Boiling point:
- 320.2±15.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Solid
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M338443
- Product name
- Methyl1-Methyl-1H-indole-6-carboxylate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR0195
- Product name
- Methyl 1-methyl-1H-indole-6-carboxylate
- Packaging
- 10g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- Z8232
- Product name
- Methyl1-methylindole-6-carboxylate
- Packaging
- 5g
- Price
- $116
- Updated
- 2021/12/16
- Product number
- 4H23-1-Y5
- Product name
- Methyl 1-methyl-1H-indole-6-carboxylate
- Purity
- 98%
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CHM0003868
- Product name
- METHYL N-METHYLINDOLE-6-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $600.79
- Updated
- 2021/12/16
AKOS B006681 Chemical Properties,Usage,Production
Synthesis
50820-65-0
74-88-4
1204-32-6
Sodium hydride (0.35 g, 8.75 mmol) was slowly added to a stirring solution of methyl 1H-indole-6-carboxylate (0.76 g, 4.34 mmol) in N,N-dimethylformamide (DMF, 10 mL) at room temperature. The resulting suspension was stirred continuously at room temperature for 30 min, followed by dropwise addition of iodomethane (0.54 mL, 8.67 mmol). The reaction mixture was continued to be stirred at room temperature for 20 hours. Upon completion of the reaction, water (20 mL) and ethyl acetate (20 mL) were added to quench the reaction. The aqueous phase was extracted with ethyl acetate (3 x 30 mL), and all organic phases were combined and dried over a phase separation column. Subsequently, the solvent was evaporated under reduced pressure to afford methyl 1-methyl-6-indolecarboxylate as an off-white solid (0.85 g, 100% yield). The product (MH+ = 190) was confirmed by LC-MS (acidic conditions). The purity of the obtained product met the requirements for subsequent use without further purification.
References
[1] Patent: WO2009/71577, 2009, A1. Location in patent: Page/Page column 43
[2] Patent: WO2010/84185, 2010, A1. Location in patent: Page/Page column 23
[3] Journal of the American Chemical Society, 2005, vol. 127, # 22, p. 8050 - 8057
[4] Chemical and Pharmaceutical Bulletin, 1999, vol. 47, # 11, p. 1538 - 1548
[5] Heterocycles, 2006, vol. 67, # 2, p. 643 - 653
AKOS B006681 Preparation Products And Raw materials
Raw materials
Preparation Products
AKOS B006681 Suppliers
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View Lastest Price from AKOS B006681 manufacturers
- Product
- Methyl 1-Methylindole-6-carboxylate 1204-32-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03