9-BENZYL-6-CHLORO-9H-PURINE
- Product Name
- 9-BENZYL-6-CHLORO-9H-PURINE
- CAS No.
- 1928-76-3
- Chemical Name
- 9-BENZYL-6-CHLORO-9H-PURINE
- Synonyms
- 6-CHLORO-9-BENZYLPURINE;9-Benyl-6-chloro-9H-purine;9-(benzyl)-6-chloro-purine;9-BENZYL-6-CHLORO-9H-PURINE;6-chloro-9-(phenylmethyl)purine;9H-Purine, 6-chloro-9-(phenylmethyl)-
- CBNumber
- CB8452612
- Molecular Formula
- C12H9ClN4
- Formula Weight
- 244.68
- MOL File
- 1928-76-3.mol
9-BENZYL-6-CHLORO-9H-PURINE Property
- Melting point:
- 86-87°C
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C365045
- Product name
- 6-Chloro-9-benzylpurine
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- C4977-41
- Product name
- 6-Chloro-9-benzylpurine
- Packaging
- 250mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- FC20175
- Product name
- 6-Chloro-9-benzylpurine
- Packaging
- 25mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC20175
- Product name
- 6-Chloro-9-benzylpurine
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC20175
- Product name
- 6-Chloro-9-benzylpurine
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
9-BENZYL-6-CHLORO-9H-PURINE Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
9-Benzyl-6-chloro-9H-purine is a useful intermediate in the synthesis of 1-substituted adenines.
Synthesis Reference(s)
The Journal of Organic Chemistry, 34, p. 1170, 1969 DOI: 10.1021/jo01256a103
Synthesis
100-39-0
87-42-3
1928-76-3
GENERAL STEPS: Benzyl bromide (0.052 mL, 0.6 mmol) was added to a mixture of 6-chloropurine (0.056 g, 0.5 mmol) and sodium hydroxide (0.014 g, 0.6 mmol) in deionized water (2 mL). The reaction mixture was placed in a microwave reactor and irradiated at 0-400 W power (internal temperature maintained at 100 °C) for 10 min. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent and the residue was purified by column chromatography using ethyl acetate-cyclohexane (9:1, v/v) as eluent to give 9-benzyl-6-chloro-9H-purine in 82% yield.
References
[1] Nucleosides, Nucleotides and Nucleic Acids, 2016, vol. 35, # 2, p. 76 - 82
[2] European Journal of Medicinal Chemistry, 2004, vol. 39, # 5, p. 433 - 447
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 3, p. 606 - 612
[4] Tetrahedron Letters, 2014, vol. 55, # 18, p. 2929 - 2931
[5] Dalton Transactions, 2014, vol. 43, # 26, p. 9838 - 9842
9-BENZYL-6-CHLORO-9H-PURINE Preparation Products And Raw materials
Raw materials
Preparation Products
9-BENZYL-6-CHLORO-9H-PURINE Suppliers
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