ChemicalBook > CAS DataBase List > (S)-3,5-DIHYDROXYPHENYLGLYCINE

(S)-3,5-DIHYDROXYPHENYLGLYCINE

Product Name
(S)-3,5-DIHYDROXYPHENYLGLYCINE
CAS No.
162870-29-3
Chemical Name
(S)-3,5-DIHYDROXYPHENYLGLYCINE
Synonyms
S-DHPG;(S)-3,5-DHPG;(S) 3,5 DHPG,(S)3,5DHPG;(S)-3,5-DIHYDROXYPHENYLGLYCINE;(S)-3,5-Dihydroxylphenylglycine;(S)-3,5-DHPG, group I mGlu agonist;(S)-3,5-Dihydroxyphenylglycine hydrate;(S)-3,5-DHPG (mM/ml), group I mGlu agonist;(S)-2-Amino-2-(3,5-dihydroxyphenyl)acetic acid;+-2,5-DIMETHOXY-4-IODOAMPHETAMINE HYDROCHLORIDE
CBNumber
CB8453891
Molecular Formula
C8H9NO4
Formula Weight
183.16
MOL File
162870-29-3.mol
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(S)-3,5-DIHYDROXYPHENYLGLYCINE Property

Melting point:
>207°C (dec.)
Boiling point:
448.8±33.0 °C(Predicted)
Density 
1.550±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Aqueous Base (Very Slightly, Sonicated), Methanol (Slightly), Water (Slightly, Heated)
form 
solid
pka
1.77±0.10(Predicted)
color 
white
Water Solubility 
Soluble to 50 mM in water
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D3689
Product name
(S)-3,5-Dihydroxyphenylglycine hydrate
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$260
Updated
2024/03/01
Sigma-Aldrich
Product number
D3689
Product name
(S)-3,5-Dihydroxyphenylglycine hydrate
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$494
Updated
2024/03/01
Cayman Chemical
Product number
14411
Product name
(S)-3,5-DHPG
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
14411
Product name
(S)-3,5-DHPG
Purity
≥98%
Packaging
5mg
Price
$126
Updated
2024/03/01
Cayman Chemical
Product number
14411
Product name
(S)-3,5-DHPG
Purity
≥98%
Packaging
10mg
Price
$220
Updated
2024/03/01
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(S)-3,5-DIHYDROXYPHENYLGLYCINE Chemical Properties,Usage,Production

Uses

(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement.

Uses

(S)-3,5-Dihydroxyphenylglycine hydrate has been used:

  • as mGluR1/5?agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations
  • in ACSF for DHPG stimulation
  • to inject into basolateral amygdala to study its effect on memory expression

Definition

ChEBI: (S)-3,5-dihydroxyphenylglycine is a glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups. It is a member of resorcinols and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-alpha-phenylglycine. It is a tautomer of a (S)-3,5-dihydroxyphenylglycine zwitterion.

Biological Activity

Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

Biochem/physiol Actions

(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.

storage

-20°C (desiccate). Protect from light.

(S)-3,5-DIHYDROXYPHENYLGLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3,5-DIHYDROXYPHENYLGLYCINE Suppliers

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162870-29-3, (S)-3,5-DIHYDROXYPHENYLGLYCINERelated Search:

(S)-3,5-DIHYDROXYPHENYLGLYCINE Vancomycin Avoparcin (±) DOI D(-)-DIHYDROXYPHENYLGLYCINE chloropolysporin B helvecardin B NORVANCOMYCIN teicoplanin aglycone chloropolysporin C Ristocetin (S)-AMINO-(3,5-DIMETHOXY-PHENYL)-ACETIC ACID helvecardin A (RS)-3,5-DIHYDROXYPHENYLGLYCINE (RS)-3,5-DIHYDROXYPHENYLGLYCINE,3,5-dihydroxyphenylglycine (2S)-2-AMINO-2-(3,5-DIHYDROXYPHENYL)PROPANOIC ACID (2S)-2-AMINO-2-[3,5-BIS(PHENYLMETHOXY)PHENYL]PROPANOIC ACID VANCOMYCIN, BODIPY(R) FL CONJUGATE

  • (S)-3,5-DIHYDROXYPHENYLGLYCINE
  • (S)-3,5-DHPG
  • S-DHPG
  • (S)-3,5-Dihydroxyphenylglycine hydrate
  • +-2,5-DIMETHOXY-4-IODOAMPHETAMINE HYDROCHLORIDE
  • (S)-3,5-Dihydroxylphenylglycine
  • Benzeneacetic acid, α-amino-3,5-dihydroxy-, (αS)-
  • (2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid
  • (S) 3,5 DHPG,(S)3,5DHPG
  • (S)-2-Amino-2-(3,5-dihydroxyphenyl)acetic acid
  • (S)-3,5-DHPG (mM/ml), group I mGlu agonist
  • (S)-3,5-DHPG, group I mGlu agonist
  • 162870-29-3
  • C8H9O4N
  • Glutamate receptor
  • Glutamate