ChemicalBook > CAS DataBase List > (S)-3,5-DIHYDROXYPHENYLGLYCINE
(S)-3,5-DIHYDROXYPHENYLGLYCINE
- Product Name
- (S)-3,5-DIHYDROXYPHENYLGLYCINE
- CAS No.
- 162870-29-3
- Chemical Name
- (S)-3,5-DIHYDROXYPHENYLGLYCINE
- Synonyms
- S-DHPG;(S)-3,5-DHPG;(S) 3,5 DHPG,(S)3,5DHPG;(S)-3,5-DIHYDROXYPHENYLGLYCINE;(S)-3,5-Dihydroxylphenylglycine;(S)-3,5-DHPG, group I mGlu agonist;(S)-3,5-Dihydroxyphenylglycine hydrate;(S)-3,5-DHPG (mM/ml), group I mGlu agonist;(S)-3,5-Dihydroxyphenylglycine hydrate;(S)-2-Amino-2-(3,5-dihydroxyphenyl)acetic acid
- CBNumber
- CB8453891
- Molecular Formula
- C8H9NO4
- Formula Weight
- 183.16
- MOL File
- 162870-29-3.mol
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(S)-3,5-DIHYDROXYPHENYLGLYCINE Property
- Melting point:
- >207°C (dec.)
- Boiling point:
- 448.8±33.0 °C(Predicted)
- Density
- 1.550±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Aqueous Base (Very Slightly, Sonicated), Methanol (Slightly), Water (Slightly, Heated)
- form
- solid
- pka
- 1.77±0.10(Predicted)
- color
- white
- Water Solubility
- Soluble to 50 mM in water
- Stability:
- Hygroscopic
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- D3689
- Product name
- (S)-3,5-Dihydroxyphenylglycine hydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $253.65
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- D3689
- Product name
- (S)-3,5-Dihydroxyphenylglycine hydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 10mg
- Price
- $533
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 14411
- Product name
- (S)-3,5-DHPG
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14411
- Product name
- (S)-3,5-DHPG
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $126
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14411
- Product name
- (S)-3,5-DHPG
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $220
- Updated
- 2024/03/01
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(S)-3,5-DIHYDROXYPHENYLGLYCINE Chemical Properties,Usage,Production
Uses
(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement.
Uses
(S)-3,5-Dihydroxyphenylglycine hydrate has been used:
- as mGluR1/5?agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations
- in ACSF for DHPG stimulation
- to inject into basolateral amygdala to study its effect on memory expression
Definition
ChEBI: (S)-3,5-dihydroxyphenylglycine is a glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups. It is a member of resorcinols and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-alpha-phenylglycine. It is a tautomer of a (S)-3,5-dihydroxyphenylglycine zwitterion.
Biological Activity
Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
Biochem/physiol Actions
(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.
storage
-20°C (desiccate). Protect from light.
(S)-3,5-DIHYDROXYPHENYLGLYCINE Preparation Products And Raw materials
Raw materials
Preparation Products
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