6-CHLOROMELATONIN
- Product Name
- 6-CHLOROMELATONIN
- CAS No.
- 63762-74-3
- Chemical Name
- 6-CHLOROMELATONIN
- Synonyms
- 6-CHLOROMELATONIN;Melatonin Impurity 8;Melatonin 6-Chloro Impurity;6 Chloromelatonin,6Chloromelatonin;N-Acetyl-6-chloro-5-methoxytryptamine;N-[2-(6-CHLORO-5-METHOXYINDOL-3-YL)ETHYL]ACETAMIDE;n-(2-(6-chloro-5-methoxy-1h-indol-3-yl)ethyl)-acetamid;N-[2-(6-Chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide;Acetamide, N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]-
- CBNumber
- CB8456892
- Molecular Formula
- C13H15ClN2O2
- Formula Weight
- 266.72
- MOL File
- 63762-74-3.mol
6-CHLOROMELATONIN Property
- Melting point:
- 147-148 °C
- Boiling point:
- 536.7±50.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- alcohol: soluble
- pka
- 15.99±0.30(Predicted)
- form
- Powder
Safety
- Hazard Codes
- T
- Risk Statements
- 60-23/24/25-36/37/38
- Safety Statements
- 53-26-36/37/39-45
- WGK Germany
- 3
- RTECS
- AB5750000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
H360May damage fertility or the unborn child
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P361Remove/Take off immediately all contaminated clothing.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 0443
- Product name
- 6-Chloromelatonin
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 0443
- Product name
- 6-Chloromelatonin
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $345
- Updated
- 2021/12/16
- Product number
- C371408
- Product name
- 6-Chloromelatonin
- Packaging
- 25mg
- Price
- $920
- Updated
- 2021/12/16
- Product number
- C371408
- Product name
- 6-Chloromelatonin
- Packaging
- 1mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 254438
- Product name
- 6-Chloromelatonin
- Packaging
- 10mg
- Price
- $339
- Updated
- 2021/12/16
6-CHLOROMELATONIN Chemical Properties,Usage,Production
Uses
6-Chloromelatonin is a potent agonist of the melatonin receptors.
Definition
ChEBI: N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide is a member of acetamides.
Biological Activity
Potent melatonin agonist (pK i values are 9.10 and 9.77 for human recombinant MT 1 and MT 2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.
in vivo
Rats injected with the melatonin agonist, 6-chloromelatonin (0.5 mg/kg) on the day after the phase shift has markedly higher excretion rates of 6-sulphatoxymelatonin compared to those of the controls[5].
IC 50
MT1: 8.9 (pKi); MT2: 9.1 (pKi)
6-CHLOROMELATONIN Preparation Products And Raw materials
Raw materials
Preparation Products
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