Glycoluril
- Product Name
- Glycoluril
- CAS No.
- 496-46-8
- Chemical Name
- Glycoluril
- Synonyms
- TETRAHYDROIMIDAZO[4,5-D]IMIDAZOLE-2,5(1H,3H)-DIONE;Acetylene carbamide;5(1H;NSC 2765;Glycouril;Glycolueil;Glycoluril;Gansu urea;Glyoxalbiuret;ACETYLENEUREA
- CBNumber
- CB8461401
- Molecular Formula
- C4H6N4O2
- Formula Weight
- 142.12
- MOL File
- 496-46-8.mol
Glycoluril Property
- Melting point:
- >300 °C (lit.)
- Boiling point:
- 259.66°C (rough estimate)
- Density
- 1.4926 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.8500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 15g/l
- form
- powder to crystal
- pka
- 12.91±0.20(Predicted)
- color
- White to Almost white
- Water Solubility
- 1.8g/L at 20℃
- Merck
- 14,93
- BRN
- 128826
- LogP
- -3.28
- CAS DataBase Reference
- 496-46-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Glycoluril(496-46-8)
- EPA Substance Registry System
- Glycoluril (496-46-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- G7305
- Product name
- Glycoluril
- Purity
- 97%
- Packaging
- 5g
- Price
- $42.75
- Updated
- 2025/07/31
- Product number
- G7305
- Product name
- Glycoluril
- Purity
- 97%
- Packaging
- 100g
- Price
- $148
- Updated
- 2025/07/31
- Product number
- G0243
- Product name
- Glycoluril
- Purity
- >98.0%(N)
- Packaging
- 25g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- 278248
- Product name
- Glycouril
- Packaging
- 100g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- G645900
- Product name
- Glycoluril
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
Glycoluril Chemical Properties,Usage,Production
Chemical Properties
WHITE TO VERY SLIGHTLY YELLOW CRYSTALLINE POWDER
Uses
Reactant involved in synthesis of:• ;Glycouril hexamers and monofunctionalized cucurbit[6]uril derivatives1,2,3• ;N-chloro compounds from trichloroisocyanuric acid4• ;Glycouril trimers5
Uses
Glycoluril is used as a reagent in the synthesis of acyclic cucurbit[n]uril molecular containers which can enhance the solubility and bioactivity of poorly soluble pharmaceuticals. Also used as a reagent in the synthesis of cucurbit[7]uril containers for targeted delivery of oxaliplatin to cancer cells.
Uses
For derivatives glycoluril, glycoluril resins
Definition
ChEBI: Glycoluril is an azabicycloalkane and a member of ureas.
Flammability and Explosibility
Not classified
Agricultural Uses
Glycine is the simplest naturally occurring amino acid and is a constituent of most proteins. Its formula is H2N·CH2·COOH.
Synthesis
131543-46-9
57-13-6
496-46-8
To a 500 mL three-necked round-bottomed flask equipped with a stirrer was added 100 mL of deionized water, glyoxal (20 g, 0.345 mol, 1.00 eq., 50 mL of a 40 wt% aqueous solution) and urea (51.7 g, 0.862 mol, 2.50 eq.). The reaction mixture was heated to 90°C and stirred for 5 minutes. Concentrated sulfuric acid (4 mL) was slowly added dropwise over 5 minutes, and a white solid formed within 10 minutes after the drop was completed. Stirring of the reaction mixture was continued for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature and 50% aqueous sodium hydroxide was added dropwise until the pH was adjusted to 14. Stirring was stopped and the reaction mixture was cooled to 0°C. The suspension was separated by vacuum filtration through a Brinell's funnel and the solids were washed with cold water (2 x 500 mL). The solid was transferred to a Brinell funnel and dried under suction for 3 h. Subsequently, it was transferred to a 700 mL beaker and dried at 80°C for 16 h. Glycuronium (1) was obtained as an off-white powder in 45.0 g (0.304 mol, 92% yield). Melting point: 335.19°C; IR (cm^-1): 3182.5 (s), 1677.0 (s); 1H NMR (90 MHz, DMSO-d6): δ 7.13 (s, 4H, -NH), 5.23 (s, 2H, N-CH-N).
References
[1] Tetrahedron Letters, 2016, vol. 57, # 15, p. 1681 - 1682
[2] Patent: WO2014/166347, 2014, A1. Location in patent: Page/Page column 13
[3] Patent: WO2015/143974, 2015, A1. Location in patent: Page/Page column 15
[4] J. Gen. Chem. USSR (Engl. Transl.), 1991, vol. 61, # 12, p. 2581 - 2582
[5] Zhurnal Obshchei Khimii, 1991, vol. 61, # 12, p. 2778 - 2780
Glycoluril Preparation Products And Raw materials
Raw materials
Preparation Products
Glycoluril Suppliers
- Tel
- 021-69005955 13701776567
- Fax
- 021-69005775
- youpengchem@163.com
- Country
- China
- ProdList
- 4161
- Advantage
- 56
- Tel
- +86-0551-62678551 +86-15056975894
- Fax
- 05512678551
- sales@hirisunpharm.com
- Country
- China
- ProdList
- 176
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +91 20 24332987
- Fax
- +91 20 24332137
- info@jpharmachem.com
- Country
- India
- ProdList
- 97
- Advantage
- 55
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 847-367-3680
- Fax
- 847-367-3681
- sales@arkpharminc.com
- Country
- United States
- ProdList
- 1670
- Advantage
- 56
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
View Lastest Price from Glycoluril manufacturers
- Product
- Glycoluril 496-46-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-11-13
- Product
- Glycoluril 496-46-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- Glycoluril 496-46-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11